{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(4)"],"submitter":["Cabrera-Wrooman A"],"pubmed_abstract":["Electrolyzed acid solutions produced by different methods have antiseptic properties due to the presence of chlorine and reactive oxygen species. Our aim was to determine whether a controlled-flow electrolyzed acid solution (CFEAS) has the ability to improve wound healing due to its antiseptic and antibiofilm properties. First, we demonstrated in vitro that Gram-negative and Gram-positive bacteria were susceptible to CFEAS, and the effect was partially sustained for 24 h, evidencing antibiofilm activity (<i>p</i> &lt; 0.05, CFEAS-treated vs. controls). The partial cytotoxicity of CFEAS was mainly observed in macrophages after 6 h of treatment; meanwhile, fibroblasts resisted short-lived free radicals (<i>p</i> &lt; 0.05, CFEAS treated vs. controls), perhaps through redox-regulating mechani"],"journal":["Microorganisms"],"pagination":["745"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9032035"],"repository":["biostudies-literature"],"pubmed_title":["Antiseptic Effects and Biosafety of a Controlled-Flow Electrolyzed Acid Solution Involve Electrochemical Properties, Rather than Free Radical Presence."],"pmcid":["PMC9032035"],"pubmed_authors":["Salgado RM","Sandoval-Cuevas B","Cabrera-Wrooman A","Ortega-Pena S","Krotzsch E"],"additional_accession":[]},"is_claimable":false,"name":"Antiseptic Effects and Biosafety of a Controlled-Flow Electrolyzed Acid Solution Involve Electrochemical Properties, Rather than Free Radical Presence.","description":"Electrolyzed acid solutions produced by different methods have antiseptic properties due to the presence of chlorine and reactive oxygen species. Our aim was to determine whether a controlled-flow electrolyzed acid solution (CFEAS) has the ability to improve wound healing due to its antiseptic and antibiofilm properties. First, we demonstrated in vitro that Gram-negative and Gram-positive bacteria were susceptible to CFEAS, and the effect was partially sustained for 24 h, evidencing antibiofilm activity (<i>p</i> &lt; 0.05, CFEAS-treated vs. controls). The partial cytotoxicity of CFEAS was mainly observed in macrophages after 6 h of treatment; meanwhile, fibroblasts resisted short-lived free radicals (<i>p</i> &lt; 0.05, CFEAS treated vs. controls), perhaps through redox-regulating mechani","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-06-01T02:56:46.743Z","creation":"2025-06-01T02:56:46.743Z"},"accession":"S-EPMC9032035","cross_references":{"pubmed":["35456795"],"doi":["10.3390/microorganisms10040745"]}}