biostudies-literatureIkeda KUCB JapanEli Lilly (Japan)Health Labour Sciences Research GrantMishima Kaiun Memorial FoundationKawasaki Medical SchoolJapan Society for the Promotion of Science4312https://www.ebi.ac.uk/biostudies/studies/S-EPMC9032572biostudies-literatureUnknown23(8)Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis. To investigate the mechanisms by which obesity and dyslipidemia exacerbate psoriasis using murine models and neonatal human epidermal keratinocytes (NHEKs), we used wild-type and <i>Apoe</i>-deficient dyslipidemic mice, and administered a high-fat diet for 10 weeks to induce obesity. Imiquimod was applied to the ear for 5 days to induce psoriatic dermatitis. To examine the innate immune responses of NHEKs, we cultured and stimulated NHEKs using IL-17A, TNF-α, palmitic acid, and leptin. We found that obesity and dyslipidemia synergistically aggravated psoriatic dermatitis associated with increased gene expreInternational journal of molecular sciencesObesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation.PMC9032572N/A20K17442Eli Lilly Japan KK Research Grant 202121K08484R03B-04620K0867220FC1047Ikeda KYahagi AHiramatsu-Asano SIseki MIshihara KTachibana KMukai TWada JMorizane SMorita YAkagi TKaneto HfalseObesity and Dyslipidemia Synergistically Exacerbate Psoriatic Skin Inflammation.Patients with psoriasis are frequently complicated with metabolic syndrome; however, it is not fully understood how obesity and dyslipidemia contribute to the pathogenesis of psoriasis. To investigate the mechanisms by which obesity and dyslipidemia exacerbate psoriasis using murine models and neonatal human epidermal keratinocytes (NHEKs), we used wild-type and <i>Apoe</i>-deficient dyslipidemic mice, and administered a high-fat diet for 10 weeks to induce obesity. Imiquimod was applied to the ear for 5 days to induce psoriatic dermatitis. To examine the innate immune responses of NHEKs, we cultured and stimulated NHEKs using IL-17A, TNF-α, palmitic acid, and leptin. We found that obesity and dyslipidemia synergistically aggravated psoriatic dermatitis associated with increased gene expre2022-01-01T00:00:00Z2022 Apr2025-04-22T03:55:33.604Z2025-04-05T20:49:45.208ZS-EPMC90325723545713210.3390/ijms23084312