{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Field MA"],"funding":["NHLBI NIH HHS","NHGRI NIH HHS"],"pagination":["eabm5944"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9032958"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(16)"],"pubmed_abstract":["Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochem"],"journal":["Science advances"],"pubmed_title":["The Australian dingo is an early offshoot of modern breed dogs."],"pmcid":["PMC9032958"],"funding_grant_id":["RM1 HG011016","U01 HL130010","UM1 HG009375","U01 HL156059"],"pubmed_authors":["Esvaran M","Keilwagen J","Rasmussen JA","Cochran BJ","Colaric Z","Rosen BD","Zammit RA","Thomas T","Yadav S","Field MA","Aiden EL","Bustamante S","Chan EKF","Smith TPL","Ballard JWO","Edwards RJ","Melvin RG","Manandhar B","Bogdanovic O","Omer A","Minoche AE","Dudchenko O","Chernoff B","Gilbert MTP","Skvortsova K"],"additional_accession":[]},"is_claimable":false,"name":"The Australian dingo is an early offshoot of modern breed dogs.","description":"Dogs are uniquely associated with human dispersal and bring transformational insight into the domestication process. Dingoes represent an intriguing case within canine evolution being geographically isolated for thousands of years. Here, we present a high-quality de novo assembly of a pure dingo (CanFam_DDS). We identified large chromosomal differences relative to the current dog reference (CanFam3.1) and confirmed no expanded pancreatic amylase gene as found in breed dogs. Phylogenetic analyses using variant pairwise matrices show that the dingo is distinct from five breed dogs with 100% bootstrap support when using Greenland wolf as the outgroup. Functionally, we observe differences in methylation patterns between the dingo and German shepherd dog genomes and differences in serum biochem","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-31T11:19:44.14Z","creation":"2024-11-20T15:50:08.751Z"},"accession":"S-EPMC9032958","cross_references":{"pubmed":["35452284"],"doi":["10.1126/sciadv.abm5944"]}}