biostudies-literatureUnknown2022Sanchez-Bezanilla S<h4>Aims</h4>We have shown that growth hormone (GH) treatment poststroke increases neuroplasticity in peri-infarct areas and the hippocampus, improving motor and cognitive outcomes. We aimed to explore the mechanisms of GH treatment by investigating how GH modulates pathways known to induce neuroplasticity, focusing on association between brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) in the peri-infarct area, hippocampus, and thalamus.<h4>Methods</h4>Recombinant human growth hormone (r-hGH) or saline was delivered (0.25 <i>μ</i>l/hr, 0.04 mg/day) to mice for 28 days, commencing 48 hours after photothrombotic stroke. Protein levels of pro-BDNF, total-mTOR, phosphorylated-mTOR, total-p70S6K, and phosporylated-p70S6K within the peri-infarct area, hippocampuNeural plasticity9983042https://www.ebi.ac.uk/biostudies/studies/S-EPMC9033347biostudies-literatureGrowth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice.PMC9033347Nilsson MAberg NDIsgaard JHood RJWalker FRSanchez-Bezanilla SBeard DJOng LKCrock PfalseGrowth Hormone Increases BDNF and mTOR Expression in Specific Brain Regions after Photothrombotic Stroke in Mice.<h4>Aims</h4>We have shown that growth hormone (GH) treatment poststroke increases neuroplasticity in peri-infarct areas and the hippocampus, improving motor and cognitive outcomes. We aimed to explore the mechanisms of GH treatment by investigating how GH modulates pathways known to induce neuroplasticity, focusing on association between brain-derived neurotrophic factor (BDNF) and mammalian target of rapamycin (mTOR) in the peri-infarct area, hippocampus, and thalamus.<h4>Methods</h4>Recombinant human growth hormone (r-hGH) or saline was delivered (0.25 <i>μ</i>l/hr, 0.04 mg/day) to mice for 28 days, commencing 48 hours after photothrombotic stroke. Protein levels of pro-BDNF, total-mTOR, phosphorylated-mTOR, total-p70S6K, and phosporylated-p70S6K within the peri-infarct area, hippocampu2022-01-01T00:00:00Z20222025-04-04T07:46:11.174Z2025-04-04T07:46:11.174ZS-EPMC90333473546539910.1155/2022/9983042