{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(32)"],"submitter":["Cortes I"],"pubmed_abstract":["A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone A was synthesized in 25.3% overall yield from the readily available pyrocatechol, whereas the second natural product was prepared in 39.7% global yield. A small library of chromones, including both natural products and some of their synthetic heterocyclic precursors, was evaluated against <i>Candida albicans</i> ATCC 10231, a biofilm forming agent. It was found that 8-methoxy-3-methyl-4-oxo-4<i>H</i>-chromene-2-carbaldehyde, a partially oxidized form of chromanone A, exhibited a minimum inhibitory concentration of 7.8 μg mL<sup>-1</s"],"journal":["RSC advances"],"pagination":["19587-19597"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9033609"],"repository":["biostudies-literature"],"pubmed_title":["First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against <i>Candida albicans</i>, a biofilm forming agent."],"pmcid":["PMC9033609"],"pubmed_authors":["Cordisco E","Bracca ABJ","Cortes I","Sortino MA","Svetaz LA","Kaufman TS"],"additional_accession":[]},"is_claimable":false,"name":"First total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against <i>Candida albicans</i>, a biofilm forming agent.","description":"A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone A was synthesized in 25.3% overall yield from the readily available pyrocatechol, whereas the second natural product was prepared in 39.7% global yield. A small library of chromones, including both natural products and some of their synthetic heterocyclic precursors, was evaluated against <i>Candida albicans</i> ATCC 10231, a biofilm forming agent. It was found that 8-methoxy-3-methyl-4-oxo-4<i>H</i>-chromene-2-carbaldehyde, a partially oxidized form of chromanone A, exhibited a minimum inhibitory concentration of 7.8 μg mL<sup>-1</s","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 May","modification":"2025-04-22T18:30:06.545Z","creation":"2024-11-08T09:28:37.146Z"},"accession":"S-EPMC9033609","cross_references":{"pubmed":["35479228"],"doi":["10.1039/d1ra02553h"]}}