biostudies-literatureUnknown11(32)Cortes IA straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone A was synthesized in 25.3% overall yield from the readily available pyrocatechol, whereas the second natural product was prepared in 39.7% global yield. A small library of chromones, including both natural products and some of their synthetic heterocyclic precursors, was evaluated against <i>Candida albicans</i> ATCC 10231, a biofilm forming agent. It was found that 8-methoxy-3-methyl-4-oxo-4<i>H</i>-chromene-2-carbaldehyde, a partially oxidized form of chromanone A, exhibited a minimum inhibitory concentration of 7.8 μg mL<sup>-1</sRSC advances19587-19597https://www.ebi.ac.uk/biostudies/studies/S-EPMC9033609biostudies-literatureFirst total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against <i>Candida albicans</i>, a biofilm forming agent.PMC9033609Cordisco EBracca ABJCortes ISortino MASvetaz LAKaufman TSfalseFirst total synthesis of chromanone A, preparation of related compounds and evaluation of their antifungal activity against <i>Candida albicans</i>, a biofilm forming agent.A straightforward and convenient approach for the first total syntheses of chromanone A and a related 7-OMe substituted natural product is reported. These unique C-3 substituted 2-hydroxymethyl chromones were recently isolated as fungal metabolites. Chromanone A was synthesized in 25.3% overall yield from the readily available pyrocatechol, whereas the second natural product was prepared in 39.7% global yield. A small library of chromones, including both natural products and some of their synthetic heterocyclic precursors, was evaluated against <i>Candida albicans</i> ATCC 10231, a biofilm forming agent. It was found that 8-methoxy-3-methyl-4-oxo-4<i>H</i>-chromene-2-carbaldehyde, a partially oxidized form of chromanone A, exhibited a minimum inhibitory concentration of 7.8 μg mL<sup>-1</s2021-01-01T00:00:00Z2021 May2025-04-22T18:30:06.545Z2024-11-08T09:28:37.146ZS-EPMC90336093547922810.1039/d1ra02553h