biostudies-literatureUnknown11(32)Zhang TSynthetic methods for the preparation of thioketals featuring CF₃ groups are rare. Here, we have developed a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans. 24 thioketal molecules have been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment has been performed giving over 95% yield. This work allows the straightforward formation of thioketals containing CF₃ groups and unsaturated double bonds.RSC advances19832-19835https://www.ebi.ac.uk/biostudies/studies/S-EPMC9033665biostudies-literatureCopper-catalyzed thioketalization of enones featuring trifluoromethyl groups.PMC9033665Zhang TGao ZfalseCopper-catalyzed thioketalization of enones featuring trifluoromethyl groups.Synthetic methods for the preparation of thioketals featuring CF₃ groups are rare. Here, we have developed a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans. 24 thioketal molecules have been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment has been performed giving over 95% yield. This work allows the straightforward formation of thioketals containing CF₃ groups and unsaturated double bonds.2021-01-01T00:00:00Z2021 May2025-04-25T22:56:43.973Z2025-04-06T09:14:16.664ZS-EPMC90336653547925510.1039/d1ra03222d