{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(33)"],"submitter":["Salim SA"],"pubmed_abstract":["Released oxygen plays a critical role in reducing destructive tumor behavior. This study aims to utilize decomposed hydrogen peroxide as an oxygen source by conjugating it with polyvinylpyrrolidone (PVP). PVP-hydrogen peroxide complex (PHP) composed of different ratios of (PVP : H<sub>2</sub>O<sub>2</sub>) (0.5 : 1, 1 : 1, 1 : 1.5, 1 : 5, and 1 : 10) were successfully synthesized. PHP complex with a ratio of 1 : 1.5 was chosen as the optimized ratio, and it was incorporated into the polymethyl methacrylate (PMMA) nanofibrous scaffold <i>via</i> the electrospinning technique. Results have revealed that the PMMA-10% PHP complex provided a significant morphological structure of nanofibrous scaffolds. The mechanical properties of PMMA-10% PHP nanofibers showed the most suitable mechanical feat"],"journal":["RSC advances"],"pagination":["19978-19991"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9033669"],"repository":["biostudies-literature"],"pubmed_title":["Novel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP-H<sub>2</sub>O<sub>2</sub> nanofibers, characterization, and <i>in vitro</i> bio-evaluation tests."],"pmcid":["PMC9033669"],"pubmed_authors":["El-Fakharany EM","Elmazar MM","Abdel-Aziz AF","Kamoun EA","Taha TH","Abou-Saleh RH","Evans S","Salaheldin TA","Salim SA"],"additional_accession":[]},"is_claimable":false,"name":"Novel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP-H<sub>2</sub>O<sub>2</sub> nanofibers, characterization, and <i>in vitro</i> bio-evaluation tests.","description":"Released oxygen plays a critical role in reducing destructive tumor behavior. This study aims to utilize decomposed hydrogen peroxide as an oxygen source by conjugating it with polyvinylpyrrolidone (PVP). PVP-hydrogen peroxide complex (PHP) composed of different ratios of (PVP : H<sub>2</sub>O<sub>2</sub>) (0.5 : 1, 1 : 1, 1 : 1.5, 1 : 5, and 1 : 10) were successfully synthesized. PHP complex with a ratio of 1 : 1.5 was chosen as the optimized ratio, and it was incorporated into the polymethyl methacrylate (PMMA) nanofibrous scaffold <i>via</i> the electrospinning technique. Results have revealed that the PMMA-10% PHP complex provided a significant morphological structure of nanofibrous scaffolds. The mechanical properties of PMMA-10% PHP nanofibers showed the most suitable mechanical feat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Jun","modification":"2025-04-25T23:00:36.409Z","creation":"2024-11-11T22:07:00.421Z"},"accession":"S-EPMC9033669","cross_references":{"pubmed":["35479904"],"doi":["10.1039/d1ra02575a"]}}