biostudies-literatureUnknown11(33)Salim SAReleased oxygen plays a critical role in reducing destructive tumor behavior. This study aims to utilize decomposed hydrogen peroxide as an oxygen source by conjugating it with polyvinylpyrrolidone (PVP). PVP-hydrogen peroxide complex (PHP) composed of different ratios of (PVP : H₂O₂) (0.5 : 1, 1 : 1, 1 : 1.5, 1 : 5, and 1 : 10) were successfully synthesized. PHP complex with a ratio of 1 : 1.5 was chosen as the optimized ratio, and it was incorporated into the polymethyl methacrylate (PMMA) nanofibrous scaffold <i>via</i> the electrospinning technique. Results have revealed that the PMMA-10% PHP complex provided a significant morphological structure of nanofibrous scaffolds. The mechanical properties of PMMA-10% PHP nanofibers showed the most suitable mechanical featRSC advances19978-19991https://www.ebi.ac.uk/biostudies/studies/S-EPMC9033669biostudies-literatureNovel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP-H₂O₂ nanofibers, characterization, and <i>in vitro</i> bio-evaluation tests.PMC9033669El-Fakharany EMElmazar MMAbdel-Aziz AFKamoun EATaha THAbou-Saleh RHEvans SSalaheldin TASalim SAfalseNovel oxygen-generation from electrospun nanofibrous scaffolds with anticancer properties: synthesis of PMMA-conjugate PVP-H₂O₂ nanofibers, characterization, and <i>in vitro</i> bio-evaluation tests.Released oxygen plays a critical role in reducing destructive tumor behavior. This study aims to utilize decomposed hydrogen peroxide as an oxygen source by conjugating it with polyvinylpyrrolidone (PVP). PVP-hydrogen peroxide complex (PHP) composed of different ratios of (PVP : H₂O₂) (0.5 : 1, 1 : 1, 1 : 1.5, 1 : 5, and 1 : 10) were successfully synthesized. PHP complex with a ratio of 1 : 1.5 was chosen as the optimized ratio, and it was incorporated into the polymethyl methacrylate (PMMA) nanofibrous scaffold <i>via</i> the electrospinning technique. Results have revealed that the PMMA-10% PHP complex provided a significant morphological structure of nanofibrous scaffolds. The mechanical properties of PMMA-10% PHP nanofibers showed the most suitable mechanical feat2021-01-01T00:00:00Z2021 Jun2025-04-25T23:00:36.409Z2024-11-11T22:07:00.421ZS-EPMC90336693547990410.1039/d1ra02575a