biostudies-literatureDopfer-Jablonka AFörderschwerpunktprogramm des COVID-19 Forschungsnetzwerks Niedersachsen (COFONI)Georg-August-Universität GöttingenFörderschwerpunktprogramm des COVID-19 Forschungsnetzwerks NiedersachsenEuropean Regional Development Fund403https://www.ebi.ac.uk/biostudies/studies/S-EPMC9035970biostudies-literatureUnknown22(1)<h4>Background</h4>Immunocompromised people (ICP) and elderly individuals (older than 80 years) are at increased risk for severe coronavirus infections. To protect against serious infection with SARS-CoV-2, ICP are taking precautions that may include a reduction of social contacts and participation in activities which they normally enjoy. Furthermore, for these people, there is an uncertainty regarding the effectiveness of the vaccination. The COVID-19 Contact (CoCo) Immune study strives to characterize the immune response to COVID-19 vaccination in immunocompromised, elderly people, and patients with hematological or oncological diseases. The study uses blood-based screenings to monitor the humoral and cellular immune response in these groups after vaccination. Questionnaires and qualitatBMC infectious diseasesSARS-CoV-2-specific immune responses in elderly and immunosuppressed participants and patients with hematologic disease or checkpoint inhibition in solid tumors: study protocol of the prospective, observational CoCo immune study.PMC90359708FT21ZW7-85152953Schroder DCossmann AHummers EFalk CSSteffens SKallusky JOverbeck TRNiewolik JHasenkamp JDopfer-Jablonka ABehrens GMNVahldiek KHeinemann SKlawonn FMuller FHeesen GMikuteit MRoder SStankov MVfalseSARS-CoV-2-specific immune responses in elderly and immunosuppressed participants and patients with hematologic disease or checkpoint inhibition in solid tumors: study protocol of the prospective, observational CoCo immune study.<h4>Background</h4>Immunocompromised people (ICP) and elderly individuals (older than 80 years) are at increased risk for severe coronavirus infections. To protect against serious infection with SARS-CoV-2, ICP are taking precautions that may include a reduction of social contacts and participation in activities which they normally enjoy. Furthermore, for these people, there is an uncertainty regarding the effectiveness of the vaccination. The COVID-19 Contact (CoCo) Immune study strives to characterize the immune response to COVID-19 vaccination in immunocompromised, elderly people, and patients with hematological or oncological diseases. The study uses blood-based screenings to monitor the humoral and cellular immune response in these groups after vaccination. Questionnaires and qualitat2022-01-01T00:00:00Z2022 Apr2025-04-05T11:40:03.649Z2024-11-19T15:00:53.839ZS-EPMC90359703546875810.1186/s12879-022-07347-w