biostudies-literatureLin HNational Natural Science Foundation of ChinaCentral University Basic Research Fund of China24232-24237https://www.ebi.ac.uk/biostudies/studies/S-EPMC9036638biostudies-literatureUnknown11(39)In this study, we found a green method to obtain aryl nitriles from aromatic aldehyde in water. This simple process was modified from a conventional method. Compared with those approaches, we used water as the solvent instead of harmful chemical reagents. In this one-pot conversion, we got twenty-five aryl nitriles conveniently with pollution to the environment being minimized. Furthermore, we confirmed the reaction mechanism by capturing the intermediates, aldoximes.RSC advancesOne pot synthesis of aryl nitriles from aromatic aldehydes in a water environment.PMC90366382170210021907051U1903201020814380151020814380140Chen QYang YQi JMa XLin HHan HWang XZhou ZfalseOne pot synthesis of aryl nitriles from aromatic aldehydes in a water environment.In this study, we found a green method to obtain aryl nitriles from aromatic aldehyde in water. This simple process was modified from a conventional method. Compared with those approaches, we used water as the solvent instead of harmful chemical reagents. In this one-pot conversion, we got twenty-five aryl nitriles conveniently with pollution to the environment being minimized. Furthermore, we confirmed the reaction mechanism by capturing the intermediates, aldoximes.2021-01-01T00:00:00Z2021 Jul2025-04-19T12:59:37.294Z2025-04-19T12:59:37.294ZS-EPMC90366383547903610.1039/d1ra03559b