{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kung PL"],"funding":["National Institute of Neurological Disorders and Stroke","NIMH NIH HHS","NINDS NIH HHS","National Institute of Mental Health","Rutgers, The State University of New Jersey","NIGMS NIH HHS"],"pagination":["100"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9036774"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(1)"],"pubmed_abstract":["<h4>Background</h4>Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease in adults. However, the potential for ZIKV to influence brain physiology and host behavior following apparently mild or subclinical infection is less well understood. Furthermore, though deficits in cognitive function are well-documented after recovery from neuroinvasive viral infection, the potential impact of ZIKV on other host behavioral domains has not been thoroughly explored.<h4>Methods</h4>We used transcriptomic profiling, including unbiased gene ontology enrichment analysis, to assess the impact of ZIKV infection on gene expression i"],"journal":["Journal of neuroinflammation"],"pubmed_title":["Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders."],"pmcid":["PMC9036774"],"funding_grant_id":["R25 GM055145","Startup Funds","R21 MH125034","DLS SURF Award","R01 NS120895-S2","R01 NS120895"],"pubmed_authors":["Chou TW","Daniels BP","Estevez I","Chang NP","Lindman M","Atkins C","Buckley BD","Kung PL"],"additional_accession":[]},"is_claimable":false,"name":"Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders.","description":"<h4>Background</h4>Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease in adults. However, the potential for ZIKV to influence brain physiology and host behavior following apparently mild or subclinical infection is less well understood. Furthermore, though deficits in cognitive function are well-documented after recovery from neuroinvasive viral infection, the potential impact of ZIKV on other host behavioral domains has not been thoroughly explored.<h4>Methods</h4>We used transcriptomic profiling, including unbiased gene ontology enrichment analysis, to assess the impact of ZIKV infection on gene expression i","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-05-30T15:28:13.512Z","creation":"2025-04-04T10:02:21.837Z"},"accession":"S-EPMC9036774","cross_references":{"pubmed":["35462541"],"doi":["10.1186/s12974-022-02460-8"]}}