biostudies-literatureMa LZShanghai Municipal Science and Technology Major ProjectExcellence 2025 Talent Cultivation Program at Fudan UniversityMedical Research CouncilNational Natural Science Foundation of China132https://www.ebi.ac.uk/biostudies/studies/S-EPMC9036798biostudies-literatureUnknown20(1)<h4>Background</h4>Data on the association between free-living daytime sunlight exposure and incident dementia are scarce. The objective is to evaluate whether the time spent in outdoor light is related to the dementia risk and to investigate whether the optimal duration varies with clinical parameters.<h4>Methods</h4>Data were from a prospective cohort of 362,094 UK Biobank participants. A questionnaire survey was conducted to investigate how many hours the participants spent outdoors on typical summer and winter days. A restricted cubic spline (RCS) was performed to explore the potential nonlinear relationship between sunlight exposure and the risk of dementia. We used multivariate Cox proportional hazard regression models to estimate the hazard ratios (HRs) for the associations between BMC medicineTime spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants.PMC9036798MC_PC_17228819710328207120130302770012018SHZDZX01MC_QA137853Tan LOu YNMa YHMa LZYang LYu JTChen SDDong QCheng WfalseTime spent in outdoor light is associated with the risk of dementia: a prospective cohort study of 362094 participants.<h4>Background</h4>Data on the association between free-living daytime sunlight exposure and incident dementia are scarce. The objective is to evaluate whether the time spent in outdoor light is related to the dementia risk and to investigate whether the optimal duration varies with clinical parameters.<h4>Methods</h4>Data were from a prospective cohort of 362,094 UK Biobank participants. A questionnaire survey was conducted to investigate how many hours the participants spent outdoors on typical summer and winter days. A restricted cubic spline (RCS) was performed to explore the potential nonlinear relationship between sunlight exposure and the risk of dementia. We used multivariate Cox proportional hazard regression models to estimate the hazard ratios (HRs) for the associations between 2022-01-01T00:00:00Z2022 Apr2025-04-22T12:58:25.98Z2024-11-13T22:37:04.365ZS-EPMC90367983546254710.1186/s12916-022-02331-2