{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rosas-Salazar C"],"funding":["NICHD NIH HHS","NCATS NIH HHS","NEI NIH HHS","NHLBI","NCRR NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS","NIAID","NIGMS NIH HHS","NIH HHS","NIGMS"],"pagination":["966-976"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9036861"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(3)"],"pubmed_abstract":["<h4>Background</h4>The risk factors determining short- and long-term morbidity following acute respiratory infection (ARI) due to respiratory syncytial virus (RSV) in infancy remain poorly understood.<h4>Objectives</h4>Our aim was to examine the associations of the upper respiratory tract (URT) microbiome during RSV ARI in infancy with the acute local immune response and short- and long-term clinical outcomes.<h4>Methods</h4>We characterized the URT microbiome by 16S ribosomal RNA sequencing and assessed the acute local immune response by measuring 53 immune mediators with high-throughput immunoassays in 357 RSV-infected infants. Our short- and long-term clinical outcomes included several markers of disease severity and the number of wheezing episodes in the fourth year of life, respective"],"journal":["The Journal of allergy and clinical immunology"],"pubmed_title":["Upper respiratory tract bacterial-immune interactions during respiratory syncytial virus infection in infancy."],"pmcid":["PMC9036861"],"funding_grant_id":["KL2 TR000446","R21 AI142321","UL1 TR000445","P30 EY008126","K24 AI077930","K01 HL149989","R01 GM140464","UG3 OD023282","U19 AI095227","P30 CA068485","R01 HL146401","UL1 RR024975","K23 HL148638","G20 RR030956","K12 HD087023","R21 AI149262","HHSN272200900007C","R21 AI154016","U19 AI110819"],"pubmed_authors":["Turi KN","Peebles RS","Chappell JD","Wiggins DA","Tang ZZ","Gebretsadik T","Anderson LJ","Hartert TV","Rosas-Salazar C","Das SR","Hong Q","Shilts MH","Lynch CE"],"additional_accession":[]},"is_claimable":false,"name":"Upper respiratory tract bacterial-immune interactions during respiratory syncytial virus infection in infancy.","description":"<h4>Background</h4>The risk factors determining short- and long-term morbidity following acute respiratory infection (ARI) due to respiratory syncytial virus (RSV) in infancy remain poorly understood.<h4>Objectives</h4>Our aim was to examine the associations of the upper respiratory tract (URT) microbiome during RSV ARI in infancy with the acute local immune response and short- and long-term clinical outcomes.<h4>Methods</h4>We characterized the URT microbiome by 16S ribosomal RNA sequencing and assessed the acute local immune response by measuring 53 immune mediators with high-throughput immunoassays in 357 RSV-infected infants. Our short- and long-term clinical outcomes included several markers of disease severity and the number of wheezing episodes in the fourth year of life, respective","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T08:53:10.102Z","creation":"2025-04-04T08:53:10.102Z"},"accession":"S-EPMC9036861","cross_references":{"pubmed":["34534566"],"doi":["10.1016/j.jaci.2021.08.022"]}}