{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Du K"],"funding":["The College Students’ innovation and entrepreneurship training program of Lanzhou University","the Key Research and Development Program of Gansu Province","the Technological Innovation Guidance Program of Gansu Province","the Key Program for International S&amp;T Cooperation Projects of China Gansu Province"],"pagination":["1212-1226"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9037217"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["37(1)"],"pubmed_abstract":["A series of novel derivatives of isaindigotone, which comes from the root of <i>isaits indinatca</i> Fort, were synthesised (Compound <b>1</b>-<b>26</b>). Four human gastrointestinal cancer cells (HCT116, PANC-1, SMMC-7721, and AGS) were employed to evaluate the anti-proliferative activity. Among them, Compound <b>6</b> displayed the most effective inhibitory activity on AGS cells with an IC<sub>50</sub> (50% inhibitory concentration) value of 2.2 μM. The potential mechanism study suggested that Compound <b>6</b> induced apoptosis in AGS cells. The collapse of mitochondrial membrane potential (MMP) in AGS cells was proved. In docking analysis, good affinity interaction between Compound <b>6</b> and AKT1 was discovered. Treatment of AGS cells with Compound <b>6</b> also resulted in signific"],"journal":["Journal of enzyme inhibition and medicinal chemistry"],"pubmed_title":["Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents."],"pmcid":["PMC9037217"],"funding_grant_id":["18YF1WA115","21CX6QA127","21YF5FA112"],"pubmed_authors":["Liu H","Hu S","Chen P","Zhang H","Ma Y","Zhu H","Yang C","Ma W","Zhou Z","Liu Y","Tian Y","Jiang X","Du K"],"additional_accession":[]},"is_claimable":false,"name":"Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents.","description":"A series of novel derivatives of isaindigotone, which comes from the root of <i>isaits indinatca</i> Fort, were synthesised (Compound <b>1</b>-<b>26</b>). Four human gastrointestinal cancer cells (HCT116, PANC-1, SMMC-7721, and AGS) were employed to evaluate the anti-proliferative activity. Among them, Compound <b>6</b> displayed the most effective inhibitory activity on AGS cells with an IC<sub>50</sub> (50% inhibitory concentration) value of 2.2 μM. The potential mechanism study suggested that Compound <b>6</b> induced apoptosis in AGS cells. The collapse of mitochondrial membrane potential (MMP) in AGS cells was proved. In docking analysis, good affinity interaction between Compound <b>6</b> and AKT1 was discovered. Treatment of AGS cells with Compound <b>6</b> also resulted in signific","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-30T15:48:26.915Z","creation":"2025-04-04T10:02:33.573Z"},"accession":"S-EPMC9037217","cross_references":{"pubmed":["35450499"],"doi":["10.1080/14756366.2022.2065672"]}}