{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(44)"],"submitter":["Si YY"],"pubmed_abstract":["Two new monoterpene indole alkaloid glycosides nutanoside A-B (1-2), two new phenolic glycoside esters nutanester A-B (6-7), together with five known compounds (3-5, 8-9) were isolated from the ethanol extract of <i>Gardneria nutans</i> Siebold & Zuccarini. Their structures were established on the basis of extensive spectroscopic analysis and TDDFT/ECD calculations. Compounds 1 and 2 are two rare monoterpene indole alkaloids with the glucosyl moiety located at C-12 and represent the first two examples of enantiomer of ajmaline type monoterpene indole alkaloids. Compounds 3, 4 and 6 displayed significant inhibitory effects on NO production in over-activated BV2 microglial cells, with the IC<sub>50</sub> values of 2.29, 6.36, and 8.78 μM, respectively. Compounds 1, 5, 7 could significantly inhibit the mRNA expression of inflammatory factors TNF-α and IL-6 induced by LPS in BV2 microglial cells at the effective concentration. Moreover, compound 3 exhibited stronger cytotoxicities against U87 and HCT116 cell lines than taxol with IC<sub>50</sub> values of 10.58 and 14.60 μM, respectively."],"journal":["RSC advances"],"pagination":["27085-27091"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9037802"],"repository":["biostudies-literature"],"pubmed_title":["Neuroinflammatory inhibitors from <i>Gardneria nutans</i> Siebold & Zuccarini."],"pmcid":["PMC9037802"],"pubmed_authors":["Sun YJ","Zhao ZZ","Xue GM","Young JI","Wang XS","Si YY","Wang WW","Feng QM","Feng WS"],"additional_accession":[]},"is_claimable":false,"name":"Neuroinflammatory inhibitors from <i>Gardneria nutans</i> Siebold & Zuccarini.","description":"Two new monoterpene indole alkaloid glycosides nutanoside A-B (1-2), two new phenolic glycoside esters nutanester A-B (6-7), together with five known compounds (3-5, 8-9) were isolated from the ethanol extract of <i>Gardneria nutans</i> Siebold & Zuccarini. Their structures were established on the basis of extensive spectroscopic analysis and TDDFT/ECD calculations. Compounds 1 and 2 are two rare monoterpene indole alkaloids with the glucosyl moiety located at C-12 and represent the first two examples of enantiomer of ajmaline type monoterpene indole alkaloids. Compounds 3, 4 and 6 displayed significant inhibitory effects on NO production in over-activated BV2 microglial cells, with the IC<sub>50</sub> values of 2.29, 6.36, and 8.78 μM, respectively. Compounds 1, 5, 7 could significantly inhibit the mRNA expression of inflammatory factors TNF-α and IL-6 induced by LPS in BV2 microglial cells at the effective concentration. Moreover, compound 3 exhibited stronger cytotoxicities against U87 and HCT116 cell lines than taxol with IC<sub>50</sub> values of 10.58 and 14.60 μM, respectively.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Aug","modification":"2025-04-05T11:07:38.852Z","creation":"2025-04-05T11:07:38.852Z"},"accession":"S-EPMC9037802","cross_references":{"pubmed":["35480696"],"doi":["10.1039/d1ra05204g"]}}