biostudies-literatureRzemieniecki TNarodowe Centrum Nauki27530-27540https://www.ebi.ac.uk/biostudies/studies/S-EPMC9037897biostudies-literatureUnknown11(44)The use of highly efficient methods and natural raw materials in syntheses of new biologically active substances addresses the current challenges in this area: ensuring the highest possible efficacy at low concentrations and reducing negative environmental impact. In the present study, we applied this strategy to obtain a new group of ionic liquids containing the indole-3-acetate anion, which is a well-known plant growth hormone, and a cation derived from a cinchona alkaloid - quinine or quinidine. A comparison of the derivatization kinetics of both alkaloids was also carried out, and the use of a quaternary quinidine derivative as a source of biologically active ionic liquids is described here for the first time. The structures of the obtained compounds were fully confirmed based on spectRSC advancesNaturally based ionic liquids with indole-3-acetate anions and cations derived from cinchona alkaloids.PMC90378972017/25/B/ST5/01622Pernak JRzemieniecki TKleiber TfalseNaturally based ionic liquids with indole-3-acetate anions and cations derived from cinchona alkaloids.The use of highly efficient methods and natural raw materials in syntheses of new biologically active substances addresses the current challenges in this area: ensuring the highest possible efficacy at low concentrations and reducing negative environmental impact. In the present study, we applied this strategy to obtain a new group of ionic liquids containing the indole-3-acetate anion, which is a well-known plant growth hormone, and a cation derived from a cinchona alkaloid - quinine or quinidine. A comparison of the derivatization kinetics of both alkaloids was also carried out, and the use of a quaternary quinidine derivative as a source of biologically active ionic liquids is described here for the first time. The structures of the obtained compounds were fully confirmed based on spect2021-01-01T00:00:00Z2021 Aug2025-04-19T13:01:56.312Z2025-04-19T13:01:56.312ZS-EPMC90378973548069810.1039/d1ra04805h