biostudies-literatureLai YLScience and Technology Planning Project of Guangdong ProvinceDepartment of Education of Guangdong ProvinceGuangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, South China University of TechnologyNatural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of China28447-28451https://www.ebi.ac.uk/biostudies/studies/S-EPMC9037987biostudies-literatureUnknown11(46)An efficient and straightforward palladium-catalyzed three-component cascade bisthiolation of terminal alkynes and arylhydrazines with sodium thiosulfate (Na₂S₂O₃) as the sulfur source for the assembly of functionalized (<i>Z</i>)-1,2-bis(arylthio)alkene derivatives is described. Using 0.5 mol% IPr-Pd-Im-Cl₂ as the catalyst, a wide range of terminal alkynes and arylhydrazines are well tolerated, thus producing the desired products in good yields with good functional group tolerance and excellent regioselectivity. Moreover, this protocol could be readily scaled up, showing potential applications in organic synthesis and material science.RSC advancesPalladium-catalyzed bisthiolation of terminal alkynes for the assembly of diverse (<i>Z</i>)-1,2-bis(arylthio)alkene derivatives.PMC90379872018KQNCX2362018B030308007219710722019B030301003Zhou LZChen ZSDu YLHe DLi JLai YLYan SfalsePalladium-catalyzed bisthiolation of terminal alkynes for the assembly of diverse (<i>Z</i>)-1,2-bis(arylthio)alkene derivatives.An efficient and straightforward palladium-catalyzed three-component cascade bisthiolation of terminal alkynes and arylhydrazines with sodium thiosulfate (Na₂S₂O₃) as the sulfur source for the assembly of functionalized (<i>Z</i>)-1,2-bis(arylthio)alkene derivatives is described. Using 0.5 mol% IPr-Pd-Im-Cl₂ as the catalyst, a wide range of terminal alkynes and arylhydrazines are well tolerated, thus producing the desired products in good yields with good functional group tolerance and excellent regioselectivity. Moreover, this protocol could be readily scaled up, showing potential applications in organic synthesis and material science.2021-01-01T00:00:00Z2021 Aug2025-04-05T11:07:20.363Z2025-04-05T11:07:20.363ZS-EPMC90379873547853610.1039/d1ra05773a