{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang X"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS"],"pagination":["e13275"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9038076"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(2)"],"pubmed_abstract":["The peritrophic matrix (PM) is an acellular membrane that covers the gut epithelium in arthropods and physically separates it from the lumen. The structure is thought to play an important role in tick biology. The PM is also known to impact the persistence of tick-borne pathogens like Borrelia burgdorferi, although limited information is available about its molecular constituents or their biological significance. Herein, we characterise a novel PM-associated gut protein in Ixodes scapularis ticks, annotated as Peritrophic Membrane Chitin Binding Protein (PM_CBP), for its role in the integrity and function of the matrix. The PM_CBP displays homology to the chitin deacetylase metalloenzyme, shows upregulation during tick feeding, and is localized at the luminal surface of the gut epithelium."],"journal":["Cellular microbiology"],"pubmed_title":["A novel tick protein supports integrity of gut peritrophic matrix impacting existence of gut microbiome and Lyme disease pathogens."],"pmcid":["PMC9038076"],"funding_grant_id":["R01 AI116620","P01 AI138949","R01 AI080615","R03 AI128232"],"pubmed_authors":["Yang X","Koci J","Yas OB","Dutta S","Rana VS","Smith AA","Pal U","Kitsou C","Zhuang X","Mongodin EF","Sharma K"],"additional_accession":[]},"is_claimable":false,"name":"A novel tick protein supports integrity of gut peritrophic matrix impacting existence of gut microbiome and Lyme disease pathogens.","description":"The peritrophic matrix (PM) is an acellular membrane that covers the gut epithelium in arthropods and physically separates it from the lumen. The structure is thought to play an important role in tick biology. The PM is also known to impact the persistence of tick-borne pathogens like Borrelia burgdorferi, although limited information is available about its molecular constituents or their biological significance. Herein, we characterise a novel PM-associated gut protein in Ixodes scapularis ticks, annotated as Peritrophic Membrane Chitin Binding Protein (PM_CBP), for its role in the integrity and function of the matrix. The PM_CBP displays homology to the chitin deacetylase metalloenzyme, shows upregulation during tick feeding, and is localized at the luminal surface of the gut epithelium.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Feb","modification":"2026-05-30T15:47:54.891Z","creation":"2025-04-04T10:02:09.382Z"},"accession":"S-EPMC9038076","cross_references":{"pubmed":["33006213"],"doi":["10.1111/cmi.13275"]}}