{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pistorius K"],"funding":["Wellcome Trust"],"pagination":["103974"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9038546"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79"],"pubmed_abstract":["<h4>Background</h4>Rheumatoid arthritis (RA) is a progressive degenerative disorder that leads to joint destruction. Available treatments only target the inflammatory component with minimal impact on joint repair. We recently uncovered a previously unappreciated family of pro-resolving mediators, the maresin conjugate in tissue regeneration (MCTR), that display both immunoregulatory and tissue-protective activities. Thus, we queried whether the production of these autacoids is disrupted in RA patients and whether they can be useful in treating joint inflammation and promoting joint repair.<h4>Methods</h4>Using a highly phenotyped RA cohort we evaluated plasma MCTR concentrations and correlated these to clinical markers of disease activity. To evaluate the immunoregulatory and tissue repara"],"journal":["EBioMedicine"],"pubmed_title":["MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis."],"pmcid":["PMC9038546"],"funding_grant_id":["107613/Z/15/Z"],"pubmed_authors":["Souza PR","Dalli J","Pitsillides A","Gomez EA","Pistorius K","Koenis DS","Rajeeve V","Spur BW","Foster J","Rodriguez AR","Sosabowski J","Pitzalis C","Hopkinson M","Ly L"],"additional_accession":[]},"is_claimable":false,"name":"MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis.","description":"<h4>Background</h4>Rheumatoid arthritis (RA) is a progressive degenerative disorder that leads to joint destruction. Available treatments only target the inflammatory component with minimal impact on joint repair. We recently uncovered a previously unappreciated family of pro-resolving mediators, the maresin conjugate in tissue regeneration (MCTR), that display both immunoregulatory and tissue-protective activities. Thus, we queried whether the production of these autacoids is disrupted in RA patients and whether they can be useful in treating joint inflammation and promoting joint repair.<h4>Methods</h4>Using a highly phenotyped RA cohort we evaluated plasma MCTR concentrations and correlated these to clinical markers of disease activity. To evaluate the immunoregulatory and tissue repara","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-22T18:26:25.674Z","creation":"2025-02-19T01:23:30.119Z"},"accession":"S-EPMC9038546","cross_references":{"pubmed":["35430453"],"doi":["10.1016/j.ebiom.2022.103974"]}}