{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Alder JK"],"funding":["NHLBI NIH HHS"],"pagination":["654-663"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9038609"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["41(5)"],"pubmed_abstract":["Background
Idiopathic pulmonary fibrosis (IPF) is the most common indication for lung transplantation in North America and variants in telomere-maintenance genes are the most common identifiable cause of IPF. We reasoned that younger IPF patients are more likely to undergo lung transplantation and we hypothesized that lung transplant recipients would be enriched for individuals with telomere-mediated disease due to the earlier onset and more severe disease in these patients.Methods
Individuals with IPF who underwent lung transplantation or were evaluated in an interstitial lung disease specialty clinic who did not undergo lung transplantation were examined. Genetic evaluation was completed via whole genome sequencing (WGS) of 426 individuals and targeted sequencing for 5 in"],"journal":["The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation"],"pubmed_title":["Lung transplantation for idiopathic pulmonary fibrosis enriches for individuals with telomere-mediated disease."],"pmcid":["PMC9038609"],"funding_grant_id":["R01 HL135062","R35 HL139860","R01 HL133184"],"pubmed_authors":["Popescu I","Shapiro SD","Morris A","Veatch M","Nouraie M","McDyer JF","Hannan SJ","Gibson KF","Alder JK","Morrell MR","Methe BA","Koshy R","Chan EG","Kass DJ","Brown M","Pilewski JM","Iasella CJ","Zhang Y","Sutton RM","Berndt A","Sanchez PG","Chen X","Saul M","Lindell KO"],"additional_accession":[]},"is_claimable":false,"name":"Lung transplantation for idiopathic pulmonary fibrosis enriches for individuals with telomere-mediated disease.","description":"Background
Idiopathic pulmonary fibrosis (IPF) is the most common indication for lung transplantation in North America and variants in telomere-maintenance genes are the most common identifiable cause of IPF. We reasoned that younger IPF patients are more likely to undergo lung transplantation and we hypothesized that lung transplant recipients would be enriched for individuals with telomere-mediated disease due to the earlier onset and more severe disease in these patients.Methods
Individuals with IPF who underwent lung transplantation or were evaluated in an interstitial lung disease specialty clinic who did not undergo lung transplantation were examined. Genetic evaluation was completed via whole genome sequencing (WGS) of 426 individuals and targeted sequencing for 5 in","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-19T13:28:46.649Z","creation":"2025-04-19T13:28:46.649Z"},"accession":"S-EPMC9038609","cross_references":{"pubmed":["34933798"],"doi":["10.1016/j.healun.2021.11.008"]}}