{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cao T"],"funding":["NHLBI NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health","NIGMS NIH HHS"],"pagination":["307-310"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9038657"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["67(5)"],"pubmed_abstract":["Many complex disease risk loci map to intergenic regions containing long intergenic noncoding RNAs (lincRNAs). The majority of these is not conserved outside humans, raising the question whether genetically regulated expression of non-conserved and conserved lincRNAs has similar rates of association with complex traits. Here we leveraged data from the Genotype-Tissue Expression (GTEx) project and multiple public genome-wide association study (GWAS) resources. Using an established transcriptome-wide association study (TWAS) tool, FUSION, we interrogated the associations between cis-regulated expression of lincRNAs and multiple cardiometabolic traits. We found that cis-regulated expression of non-conserved lincRNAs had a strikingly similar trend of association with complex cardiometabolic tr"],"journal":["Journal of human genetics"],"pubmed_title":["Cis-regulated expression of non-conserved lincRNAs associates with cardiometabolic related traits."],"pmcid":["PMC9038657"],"funding_grant_id":["R01 GM127862","R15 GM126485","R01 HL132561","R01 HL113147","K24 HL107643"],"pubmed_authors":["Lumish H","O'Reilly ME","Xue C","Reilly MP","Jha A","Cao T","Selvaggi C","Cynn E","Foulkes AS"],"additional_accession":[]},"is_claimable":false,"name":"Cis-regulated expression of non-conserved lincRNAs associates with cardiometabolic related traits.","description":"Many complex disease risk loci map to intergenic regions containing long intergenic noncoding RNAs (lincRNAs). The majority of these is not conserved outside humans, raising the question whether genetically regulated expression of non-conserved and conserved lincRNAs has similar rates of association with complex traits. Here we leveraged data from the Genotype-Tissue Expression (GTEx) project and multiple public genome-wide association study (GWAS) resources. Using an established transcriptome-wide association study (TWAS) tool, FUSION, we interrogated the associations between cis-regulated expression of lincRNAs and multiple cardiometabolic traits. We found that cis-regulated expression of non-conserved lincRNAs had a strikingly similar trend of association with complex cardiometabolic tr","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-04T22:33:42.523Z","creation":"2025-02-19T03:23:59.389Z"},"accession":"S-EPMC9038657","cross_references":{"pubmed":["35017681"],"doi":["10.1038/s10038-022-01012-5"]}}