{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shoda T"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","NIAID NIH HHS"],"pagination":["1635-1649"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9038694"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["162(6)"],"pubmed_abstract":["<h4>Background & aims</h4>Colonic eosinophilia, an enigmatic finding often referred to as eosinophilic colitis (EoC), is a poorly understood condition. Whether EoC is a distinct disease or a colonic manifestation of eosinophilic gastrointestinal diseases (EGIDs) or inflammatory bowel disease (IBD) is undetermined.<h4>Methods</h4>Subjects with EoC (n = 27) and controls (normal [NL, n = 20], Crohn's disease [CD, n = 14]) were enrolled across sites associated with the Consortium of Eosinophilic Gastrointestinal Disease Researchers. EoC was diagnosed as colonic eosinophilia (ascending ≥100, descending ≥85, sigmoid ≥65 eosinophils/high-power field) with related symptoms. Colon biopsies were subjected to RNA sequencing. Associations between gene expression and histologic features were analyzed w"],"journal":["Gastroenterology"],"pubmed_title":["Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study."],"pmcid":["PMC9038694"],"funding_grant_id":["U01 AI126614","R00 AI158660","U54 AI117804","P30 DK078392","U2C TR002818","UM2 AI130836","R01 AI135197","K99 AI158660"],"pubmed_authors":["Bailey D","Wilkey L","Spergel AR","Wheatley L","Atkins F","Gonsalves N","Furuta GT","Osswald GA","Martin E","Martin L","Aceves SS","Khosh-Hemmat E","Spergel JM","Hiremath G","Davis CM","Knowles J","Kyle S","Nhu Q","Peterson K","Arva NC","Foss K","Krischer J","Liacouras C","Furuta G","Poppendeck H","Cahoon J","Levy M","DiTommaso L","Bolton S","Hamilton F","Keeley K","Geno D","Olive A","Friedlander J","Dohil R","Foote H","Chehade M","Gupta SK","Andrews R","Wershil B","Oyibo OJ","Murray-Petzold C","Yang GY","Sinanovic S","Shoda T","Anvari S","Gupta S","Tran D","Katzka D","Tomkinson T","Aceves S","Collins MH","Hirano I","Schoepfer A","Kodroff E","Eby M","Mingler M","Rivera F","Strobel MJ","Besl B","Fleischer D","Mukkada VA","Wechsler JB","Arva N","Menard-Katcher C","Pesek R","Tasco A","Thompson K","Tholen C","Wen T","Denson LA","Tylicki A","Mack LE","Menard-Katcher P","Davis C","Caldwell JM","Capocelli KE","Newbury R","Mendoza G","Kaseta T","DeMarshall M","Sun K","Holland-Thomas N","McCright-Gill T","Spergel J","Kocher K","Berry A","Burke D","Haberman Y","Mack D","Falk GW","Urv T","Arrington A","Dellon E","Greuter T","Putnam PE","Consortium of Eosinophilic Gastrointestinal Diseases Researchers (CEGIR)","Rothenberg M","Zicarelli A","Chiou E","Fulkerson P","Falk G","Wang ML","Kagalwalla A","Pablo Abonia J","Bray K","Leung J","Sheridan R","Khoury P","Scott M","Almonte S","Burger C","Muir A","Sable K","Capocelli K","Kliewer K","Pan Z","King E","Paliana A","Jacinto L","Minnicozzi M","Rothenberg ME","Book W","Zalewski A","Dellon ES","Klion A","Wechsler J","Besse JA","Rochman M","Mukkada V","Collins M","Harris J","Brown T","Putnam P","Bonis P","Harris K"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating Eosinophilic Colitis as a Unique Disease Using Colonic Molecular Profiles: A Multi-Site Study.","description":"<h4>Background & aims</h4>Colonic eosinophilia, an enigmatic finding often referred to as eosinophilic colitis (EoC), is a poorly understood condition. Whether EoC is a distinct disease or a colonic manifestation of eosinophilic gastrointestinal diseases (EGIDs) or inflammatory bowel disease (IBD) is undetermined.<h4>Methods</h4>Subjects with EoC (n = 27) and controls (normal [NL, n = 20], Crohn's disease [CD, n = 14]) were enrolled across sites associated with the Consortium of Eosinophilic Gastrointestinal Disease Researchers. EoC was diagnosed as colonic eosinophilia (ascending ≥100, descending ≥85, sigmoid ≥65 eosinophils/high-power field) with related symptoms. Colon biopsies were subjected to RNA sequencing. Associations between gene expression and histologic features were analyzed w","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-19T13:27:49.367Z","creation":"2024-11-11T22:52:41.732Z"},"accession":"S-EPMC9038694","cross_references":{"pubmed":["35085569"],"doi":["10.1053/j.gastro.2022.01.022"]}}