{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lv Y"],"funding":["National Natural Science Foundation of China","Science and Technology Major Project of Anhui Province","100-Talent Program of Chinese Academy of Sciences"],"pagination":["29"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9038980"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Background
The chromodomain helicase DNA-binding (CHD) family, a group of genes that regulate nucleosome spacing and access to transcription factors, contributes to tumorigenesis in various cancers. However, the roles of CHD family members in lung cancer remain poorly understood.Methods
We investigated the transcriptional, survival, and immune data of CHDs in patients with lung cancer from the Oncomine, UALCAN, GEPIA, Kaplan-Meier Plotter, TCGA, TIMER, cBioPortal, and CR2Cancer databases. Then, perform functional enrichment analysis of CHDs was performed using the Metascape. Finally, the expression of CHD7, CHD8 and DNA damage response genes were evaluated by quantitative real-time PCR and western blot.The effects of CHD7 or CHD8 knockdown on A549 and PC9 cells were measure"],"journal":["Discover. Oncology"],"pubmed_title":["Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer."],"pmcid":["PMC9038980"],"funding_grant_id":["18030801140","81972191"],"pubmed_authors":["Lv Y","Lin W"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensive analysis of the expression, prognosis, and immune infiltrates for CHDs in human lung cancer.","description":"Background
The chromodomain helicase DNA-binding (CHD) family, a group of genes that regulate nucleosome spacing and access to transcription factors, contributes to tumorigenesis in various cancers. However, the roles of CHD family members in lung cancer remain poorly understood.Methods
We investigated the transcriptional, survival, and immune data of CHDs in patients with lung cancer from the Oncomine, UALCAN, GEPIA, Kaplan-Meier Plotter, TCGA, TIMER, cBioPortal, and CR2Cancer databases. Then, perform functional enrichment analysis of CHDs was performed using the Metascape. Finally, the expression of CHD7, CHD8 and DNA damage response genes were evaluated by quantitative real-time PCR and western blot.The effects of CHD7 or CHD8 knockdown on A549 and PC9 cells were measure","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-26T15:13:20.917Z","creation":"2025-04-06T14:52:03.686Z"},"accession":"S-EPMC9038980","cross_references":{"pubmed":["35467222"],"doi":["10.1007/s12672-022-00489-y"]}}