{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yin W"],"funding":["National Natural Science Foundation of China"],"pagination":["100257"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9039997"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["Glycated protein is a kind of promising material that can improve the bioavailability of bioactive compounds and achieve sustained release under digestion. In this study, the α-lactalbumin (ALA)-dextran conjugates synthesized by Maillard reaction were fabricated to load and protect quercetin. Quercetin-loaded micelles stabilized by the ALA-dextran conjugates 1:4 showed the smallest size (428.57 ± 5.64 nm) with highest encapsulation efficiency (94.38% ± 0.50%) of quercetin. Compared to ALA/dextran mixture complex, the conjugates-based micelles had better pH, ionic strength and photothermal stability. Furthermore, the micelles composed of the conjugates 1:2 and 1:4 showed the best controlled release effect during the simulated digestion, releasing 62.41% and 66.15% of quercetin from the tota"],"journal":["Food chemistry: X"],"pubmed_title":["Glycated α-lactalbumin based micelles for quercetin delivery: Physicochemical stability and fate of simulated digestion."],"pmcid":["PMC9039997"],"funding_grant_id":["32101983"],"pubmed_authors":["Song L","Yin W","Huang Y","Ma L","Hu X","Chen F","Ji J"],"additional_accession":[]},"is_claimable":false,"name":"Glycated α-lactalbumin based micelles for quercetin delivery: Physicochemical stability and fate of simulated digestion.","description":"Glycated protein is a kind of promising material that can improve the bioavailability of bioactive compounds and achieve sustained release under digestion. In this study, the α-lactalbumin (ALA)-dextran conjugates synthesized by Maillard reaction were fabricated to load and protect quercetin. Quercetin-loaded micelles stabilized by the ALA-dextran conjugates 1:4 showed the smallest size (428.57 ± 5.64 nm) with highest encapsulation efficiency (94.38% ± 0.50%) of quercetin. Compared to ALA/dextran mixture complex, the conjugates-based micelles had better pH, ionic strength and photothermal stability. Furthermore, the micelles composed of the conjugates 1:2 and 1:4 showed the best controlled release effect during the simulated digestion, releasing 62.41% and 66.15% of quercetin from the tota","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T07:44:27.315Z","creation":"2025-04-04T07:44:27.315Z"},"accession":"S-EPMC9039997","cross_references":{"pubmed":["35499028"],"doi":["10.1016/j.fochx.2022.100257"]}}