{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Kumari S"],"funding":["Department of Science and Technology","Council of Scientific &amp; Industrial Research","University Grants Commission Department of Atomic Energy Consortium for Scientific Research","Department of Biotechnology","ICMR"],"pubmed_abstract":["Recently, we showed how an early restriction of gut flora proliferation by <i>Plasmodium vivax</i> favors immune-suppression and <i>Plasmodium</i> survival in the gut lumen (Sharma et al., 2020). Here, we asked post gut invasion how <i>P. vivax</i> interacts with individual tissues such as the midgut, hemocyte, and salivary glands, and manages its survival in the mosquito host. Our data from tissue-specific comparative RNA-Seq analysis and extensive temporal/spatial expression profiling of selected mosquito transcripts in the uninfected and <i>P. vivax</i> infected mosquito's tissues indicated that (i) a transient suppression of gut metabolic machinery by early oocysts; (ii) enriched expression of nutritional responsive proteins and immune proteins against late oocysts, together may ensure"],"journal":["Current research in immunology"],"pagination":["12-22"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9040150"],"repository":["biostudies-literature"],"pubmed_title":["Genetic changes of <i>Plasmodium vivax</i> tempers host tissue-specific responses in <i>Anopheles stephensi</i>."],"pmcid":["PMC9040150"],"pubmed_authors":["Pandey KC","Chauhan C","Pande V","Dixit R","De TD","Sharma P","Rani J","Kumari S","Singla D","Thomas T","Tevatiya S","Savargaonkar D"],"additional_accession":[]},"is_claimable":false,"name":"Genetic changes of <i>Plasmodium vivax</i> tempers host tissue-specific responses in <i>Anopheles stephensi</i>.","description":"Recently, we showed how an early restriction of gut flora proliferation by <i>Plasmodium vivax</i> favors immune-suppression and <i>Plasmodium</i> survival in the gut lumen (Sharma et al., 2020). Here, we asked post gut invasion how <i>P. vivax</i> interacts with individual tissues such as the midgut, hemocyte, and salivary glands, and manages its survival in the mosquito host. Our data from tissue-specific comparative RNA-Seq analysis and extensive temporal/spatial expression profiling of selected mosquito transcripts in the uninfected and <i>P. vivax</i> infected mosquito's tissues indicated that (i) a transient suppression of gut metabolic machinery by early oocysts; (ii) enriched expression of nutritional responsive proteins and immune proteins against late oocysts, together may ensure","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-09T19:20:47.34Z","creation":"2025-04-25T18:08:14.594Z"},"accession":"S-EPMC9040150","cross_references":{"pubmed":["35492403"],"doi":["10.1016/j.crimmu.2021.02.002"]}}