biostudies-literatureUnknown2Kumari SDepartment of Science and TechnologyCouncil of Scientific &amp; Industrial ResearchUniversity Grants Commission Department of Atomic Energy Consortium for Scientific ResearchDepartment of BiotechnologyICMRRecently, we showed how an early restriction of gut flora proliferation by <i>Plasmodium vivax</i> favors immune-suppression and <i>Plasmodium</i> survival in the gut lumen (Sharma et al., 2020). Here, we asked post gut invasion how <i>P. vivax</i> interacts with individual tissues such as the midgut, hemocyte, and salivary glands, and manages its survival in the mosquito host. Our data from tissue-specific comparative RNA-Seq analysis and extensive temporal/spatial expression profiling of selected mosquito transcripts in the uninfected and <i>P. vivax</i> infected mosquito's tissues indicated that (i) a transient suppression of gut metabolic machinery by early oocysts; (ii) enriched expression of nutritional responsive proteins and immune proteins against late oocysts, together may ensureCurrent research in immunology12-22https://www.ebi.ac.uk/biostudies/studies/S-EPMC9040150biostudies-literatureGenetic changes of <i>Plasmodium vivax</i> tempers host tissue-specific responses in <i>Anopheles stephensi</i>.PMC9040150Pandey KCChauhan CPande VDixit RDe TDSharma PRani JKumari SSingla DThomas TTevatiya SSavargaonkar DfalseGenetic changes of <i>Plasmodium vivax</i> tempers host tissue-specific responses in <i>Anopheles stephensi</i>.Recently, we showed how an early restriction of gut flora proliferation by <i>Plasmodium vivax</i> favors immune-suppression and <i>Plasmodium</i> survival in the gut lumen (Sharma et al., 2020). Here, we asked post gut invasion how <i>P. vivax</i> interacts with individual tissues such as the midgut, hemocyte, and salivary glands, and manages its survival in the mosquito host. Our data from tissue-specific comparative RNA-Seq analysis and extensive temporal/spatial expression profiling of selected mosquito transcripts in the uninfected and <i>P. vivax</i> infected mosquito's tissues indicated that (i) a transient suppression of gut metabolic machinery by early oocysts; (ii) enriched expression of nutritional responsive proteins and immune proteins against late oocysts, together may ensure2021-01-01T00:00:00Z20212026-05-09T19:20:47.34Z2025-04-25T18:08:14.594ZS-EPMC90401503549240310.1016/j.crimmu.2021.02.002