biostudies-literatureUnknown34(4)Sartaj Sohrab SKing Abdulaziz University<h4>Objective</h4>The acute cases of pneumonia (COVID-19) were first reported from China in December 2019, and the pathogen was identified as SARS-CoV-2. Currently, many vaccines have been developed against this virus by using multiple genes, applying different platforms, and used for the vaccinations of the human population. Spike protein genes play an important role in host cell attachment and viral entry and have been extensively used for the development of vaccine and antiviral therapeutics. Short interfering RNA is also known as silencing RNA and contribute a significant role to regulate the expression of a specific gene. By using this technology, virus inhibition has been demonstrated against many viral diseases.<h4>Methods</h4>In this work, we have reported the Insilico prediction, Journal of King Saud University. Science102049https://www.ebi.ac.uk/biostudies/studies/S-EPMC9040457biostudies-literatureIn silico prediction and experimental evaluation of potential siRNAs against SARS-CoV-2 inhibition in Vero E6 cells.PMC9040457Sartaj Sohrab SAly El-Kafrawy SIbraheem Azhar EfalseIn silico prediction and experimental evaluation of potential siRNAs against SARS-CoV-2 inhibition in Vero E6 cells.<h4>Objective</h4>The acute cases of pneumonia (COVID-19) were first reported from China in December 2019, and the pathogen was identified as SARS-CoV-2. Currently, many vaccines have been developed against this virus by using multiple genes, applying different platforms, and used for the vaccinations of the human population. Spike protein genes play an important role in host cell attachment and viral entry and have been extensively used for the development of vaccine and antiviral therapeutics. Short interfering RNA is also known as silencing RNA and contribute a significant role to regulate the expression of a specific gene. By using this technology, virus inhibition has been demonstrated against many viral diseases.<h4>Methods</h4>In this work, we have reported the Insilico prediction, 2022-01-01T00:00:00Z2022 Jun2025-04-04T19:32:08.585Z2025-02-19T02:58:10.97ZS-EPMC90404573549370910.1016/j.jksus.2022.102049