{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li T"],"funding":["National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province"],"pagination":["29376-29384"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9040573"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(47)"],"pubmed_abstract":["Eight previously undescribed diarylheptanoids (1-8), together with fifteen known analogues (9-23), were isolated from the rhizomes of <i>Zingiber officinale</i>. Their structures were unambiguously determined by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. It is worth mentioning that 1-3 are the first reported structures of diaryl ether heptanoids in <i>Z. officinale</i>, whereas 15-17 were isolated from <i>Zingiber</i> for the first time. Furthermore, a gene enrichment analysis of the interacting targets indicated that diarylheptanoids were mainly associated with the anti-tumor activity by affecting DNA damage signaling pathway. The results showed that 6, 16-19 had remarkable inhibitory effects against five tumor cell lines (A549, HepG2, HeLa,"],"journal":["RSC advances"],"pubmed_title":["Diarylheptanoid analogues from the rhizomes of <i>Zingiber officinale</i> and their anti-tumour activity."],"pmcid":["PMC9040573"],"funding_grant_id":["2018A030313707","81803347"],"pubmed_authors":["Pang QQ","Zhou M","Yao XJ","Li HB","Li T","Pan DB","Yao XS","Yu Y"],"additional_accession":[]},"is_claimable":false,"name":"Diarylheptanoid analogues from the rhizomes of <i>Zingiber officinale</i> and their anti-tumour activity.","description":"Eight previously undescribed diarylheptanoids (1-8), together with fifteen known analogues (9-23), were isolated from the rhizomes of <i>Zingiber officinale</i>. Their structures were unambiguously determined by comprehensive spectroscopic analyses and electronic circular dichroism (ECD) calculations. It is worth mentioning that 1-3 are the first reported structures of diaryl ether heptanoids in <i>Z. officinale</i>, whereas 15-17 were isolated from <i>Zingiber</i> for the first time. Furthermore, a gene enrichment analysis of the interacting targets indicated that diarylheptanoids were mainly associated with the anti-tumor activity by affecting DNA damage signaling pathway. The results showed that 6, 16-19 had remarkable inhibitory effects against five tumor cell lines (A549, HepG2, HeLa,","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-22T07:48:22.77Z","creation":"2025-04-05T22:18:30.256Z"},"accession":"S-EPMC9040573","cross_references":{"pubmed":["35479564"],"doi":["10.1039/d1ra03592d"]}}