{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ray SC"],"funding":["NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases","HHS | NIH | National Institute of Allergy and Infectious Diseases (NIAID)"],"pagination":["e0377321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9040751"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(2)"],"pubmed_abstract":["Intracellular pathogens residing within macrophage phagosomes are challenged with recognizing the phagosomal environment and appropriately responding to changing host defense strategies imposed in this organelle. One such phagocyte defense is the restriction of available copper as a form of nutritional immunity during the adaptive immune response to fungal pathogens. The intracellular fungal pathogen Histoplasma capsulatum adapts to this decreased copper through upregulation of the Ctr3 copper transporter. In this study, we show that <i>Histoplasma</i> recognizes the characteristic low-copper phagosomal environment of activated macrophages through the copper-dependent transcriptional regulator Mac1. Multiple <i>cis</i>-acting regulatory sequences in the <i>CTR3</i> promoter control upregul"],"journal":["mBio"],"pubmed_title":["Mac1-Dependent Copper Sensing Promotes <i>Histoplasma</i> Adaptation to the Phagosome during Adaptive Immunity."],"pmcid":["PMC9040751"],"funding_grant_id":["T32-AI112542","R21-AI137714","R21 AI137714","T32 AI112542"],"pubmed_authors":["Rappleye CA","Ray SC"],"additional_accession":[]},"is_claimable":false,"name":"Mac1-Dependent Copper Sensing Promotes <i>Histoplasma</i> Adaptation to the Phagosome during Adaptive Immunity.","description":"Intracellular pathogens residing within macrophage phagosomes are challenged with recognizing the phagosomal environment and appropriately responding to changing host defense strategies imposed in this organelle. One such phagocyte defense is the restriction of available copper as a form of nutritional immunity during the adaptive immune response to fungal pathogens. The intracellular fungal pathogen Histoplasma capsulatum adapts to this decreased copper through upregulation of the Ctr3 copper transporter. In this study, we show that <i>Histoplasma</i> recognizes the characteristic low-copper phagosomal environment of activated macrophages through the copper-dependent transcriptional regulator Mac1. Multiple <i>cis</i>-acting regulatory sequences in the <i>CTR3</i> promoter control upregul","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-10T06:20:19.309Z","creation":"2024-11-21T07:11:19.762Z"},"accession":"S-EPMC9040751","cross_references":{"pubmed":["35404120"],"doi":["10.1128/mbio.03773-21"]}}