{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li W"],"funding":["Natural Science Foundation of Shandong Province","National Natural Science Foundation of China"],"pagination":["29684-29689"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9040924"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(47)"],"pubmed_abstract":["Two unique trinorlabdane diterpenoid alkaloids, forsyqinlingines A (1) and B (2), were isolated from the ripe fruits of <i>Forsythia suspensa</i>. Their structures, including absolute stereochemical configurations, were fully elucidated from extensive spectroscopy experiments, single-crystal X-ray diffraction, and electronic circular dichroism (ECD). In addition, a plausible biosynthetic pathway for the formation of compounds 1 and 2 in <i>Forsythia suspensa</i> was also proposed. <i>In vitro</i>, the two C<sub>17</sub>-labdane diterpenoid alkaloids exhibited anti-inflammatory activities by inhibiting the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs), and antiviral activities against influenza A (H1N1) virus and respiratory syncytial virus (RSV)."],"journal":["RSC advances"],"pubmed_title":["Trinorlabdane diterpenoid alkaloids featuring an unprecedented skeleton with anti-inflammatory and anti-viral activities from <i>Forsythia suspensa</i>."],"pmcid":["PMC9040924"],"funding_grant_id":["21372189","ZR2019HM091"],"pubmed_authors":["Li W","Xie ZP","Zhao L","Sun LT","Zhang SM","Dai SJ","Yue XD"],"additional_accession":[]},"is_claimable":false,"name":"Trinorlabdane diterpenoid alkaloids featuring an unprecedented skeleton with anti-inflammatory and anti-viral activities from <i>Forsythia suspensa</i>.","description":"Two unique trinorlabdane diterpenoid alkaloids, forsyqinlingines A (1) and B (2), were isolated from the ripe fruits of <i>Forsythia suspensa</i>. Their structures, including absolute stereochemical configurations, were fully elucidated from extensive spectroscopy experiments, single-crystal X-ray diffraction, and electronic circular dichroism (ECD). In addition, a plausible biosynthetic pathway for the formation of compounds 1 and 2 in <i>Forsythia suspensa</i> was also proposed. <i>In vitro</i>, the two C<sub>17</sub>-labdane diterpenoid alkaloids exhibited anti-inflammatory activities by inhibiting the release of β-glucuronidase in rat polymorphonuclear leukocytes (PMNs), and antiviral activities against influenza A (H1N1) virus and respiratory syncytial virus (RSV).","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-04T07:44:07.065Z","creation":"2025-04-04T07:44:07.065Z"},"accession":"S-EPMC9040924","cross_references":{"pubmed":["35479562"],"doi":["10.1039/d1ra05760j"]}}