{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Peng D"],"funding":["Vetenskapsrådet","Jeanssons Stiftelser","Deutsche Forschungsgemeinschaft","NIMH NIH HHS","NHLBI NIH HHS","Knut och Alice Wallenbergs Stiftelse","National Institutes of Health","Ragnar Söderbergs stiftelse"],"pagination":["e74094"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9042226"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11"],"pubmed_abstract":["The migration of lymphatic endothelial cells (LECs) is key for the development of the complex and vast lymphatic vascular network that pervades most tissues in an organism. In zebrafish, arterial intersegmental vessels together with chemokines have been shown to promote lymphatic cell migration from the horizontal myoseptum (HM). We observed that emergence of mural cells around the intersegmental arteries coincides with lymphatic departure from HM which raised the possibility that arterial mural cells promote LEC migration. Our live imaging and cell ablation experiments revealed that LECs migrate slower and fail to establish the lymphatic vascular network in the absence of arterial mural cells. We determined that mural cells are a source for the C-X-C motif chemokine 12 (Cxcl12a and Cxcl12"],"journal":["eLife"],"pubmed_title":["Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells."],"pmcid":["PMC9042226"],"funding_grant_id":["CRC1348B08","K23 MH002016","M13/17","VR-MH-2016-01437","2017.0144","R35HL140017","R35 HL140017"],"pubmed_authors":["Hußmann M","Fukuhara S","Lawson ND","Peng D","Mochizuki N","Koltowska K","Ando K","Gloger M","Skoczylas R","Schulte-Merker S","Betsholtz C"],"additional_accession":[]},"is_claimable":false,"name":"Proper migration of lymphatic endothelial cells requires survival and guidance cues from arterial mural cells.","description":"The migration of lymphatic endothelial cells (LECs) is key for the development of the complex and vast lymphatic vascular network that pervades most tissues in an organism. In zebrafish, arterial intersegmental vessels together with chemokines have been shown to promote lymphatic cell migration from the horizontal myoseptum (HM). We observed that emergence of mural cells around the intersegmental arteries coincides with lymphatic departure from HM which raised the possibility that arterial mural cells promote LEC migration. Our live imaging and cell ablation experiments revealed that LECs migrate slower and fail to establish the lymphatic vascular network in the absence of arterial mural cells. We determined that mural cells are a source for the C-X-C motif chemokine 12 (Cxcl12a and Cxcl12","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-31T12:58:57.935Z","creation":"2025-04-06T21:49:21.917Z"},"accession":"S-EPMC9042226","cross_references":{"pubmed":["35316177"],"doi":["10.7554/eLife.74094"]}}