{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mu Y"],"funding":["Specific Research Project of Guangxi for Research Bases and Talents","Science and Technology Major Project of Guangxi"],"pagination":["35011-35019"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9042891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(55)"],"pubmed_abstract":["Six oxazolomycins (1-6) were isolated from the fermentation broth of a soil-borne bacterial strain, <i>Streptomyces glaucus</i>. The structures of the new compounds, oxazolomycins D-F (1-3) and glaucumycins A, B (6a/6b), were elucidated by detailed spectroscopic data analysis. Oxazolomycins 1, 2, 4, and 5 demonstrated weak or modest cytotoxic activities against four human cancer cell lines, with IC<sub>50</sub> values ranging from 10.6 ± 1.7 to 89.5 ± 6.6 μM (or >100 μM). Further study showed that 4 caused S phase cell cycle arrest in SMMC7721 cells through down-regulating the protein expression of cyclin A2, CDK2. Meanwhile, 4 induced apoptosis in SMMC7721 cells through down-regulating the protein levels of Bcl-2, up-regulating the levels of Bax, and activating the cleavage of caspase-3."],"journal":["RSC advances"],"pubmed_title":["Oxazolomycins produced by <i>Streptomyces glaucus</i> and their cytotoxic activity."],"pmcid":["PMC9042891"],"funding_grant_id":["AD18281066","AA18242026"],"pubmed_authors":["Jiang Y","Li G","Mu Y","Han L","Tan J","Huang X","Qu X","Liu B","Jiang M","Li L"],"additional_accession":[]},"is_claimable":false,"name":"Oxazolomycins produced by <i>Streptomyces glaucus</i> and their cytotoxic activity.","description":"Six oxazolomycins (1-6) were isolated from the fermentation broth of a soil-borne bacterial strain, <i>Streptomyces glaucus</i>. The structures of the new compounds, oxazolomycins D-F (1-3) and glaucumycins A, B (6a/6b), were elucidated by detailed spectroscopic data analysis. Oxazolomycins 1, 2, 4, and 5 demonstrated weak or modest cytotoxic activities against four human cancer cell lines, with IC<sub>50</sub> values ranging from 10.6 ± 1.7 to 89.5 ± 6.6 μM (or >100 μM). Further study showed that 4 caused S phase cell cycle arrest in SMMC7721 cells through down-regulating the protein expression of cyclin A2, CDK2. Meanwhile, 4 induced apoptosis in SMMC7721 cells through down-regulating the protein levels of Bcl-2, up-regulating the levels of Bax, and activating the cleavage of caspase-3.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-31T23:16:59.13Z","creation":"2024-10-17T19:59:26.936Z"},"accession":"S-EPMC9042891","cross_references":{"pubmed":["35494745"],"doi":["10.1039/d1ra06182h"]}}