{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["79(5)"],"submitter":["Deroyer C"],"funding":["Fond d’Investissement pour la Recherche Scientifique","Crédit Sectoriel de Recherche en Sciences de la Santé"],"pubmed_abstract":["Osteoarthritis (OA) synovial membrane is mainly characterized by low-grade inflammation, hyperplasia with increased cell proliferation and fibrosis. We previously underscored a critical role for CEMIP in fibrosis of OA cartilage. However, its role in OA synovial membrane remains unknown. An in vitro model with fibroblast-like synoviocytes from OA patients and an in vivo model with collagenase-induced OA mice were used to evaluate CEMIP-silencing effects on inflammation, hyperplasia and fibrosis. Our results showed that i. CEMIP expression was increased in human and mouse inflamed synovial membrane; ii. CEMIP regulated the inflammatory response pathway and inflammatory cytokines production in vitro and in vivo; iii. CEMIP induced epithelial to mesenchymal transition pathway and fibrotic mar"],"journal":["Cellular and molecular life sciences : CMLS"],"pagination":["260"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9042994"],"repository":["biostudies-literature"],"pubmed_title":["CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane."],"pmcid":["PMC9042994"],"pubmed_authors":["Paulissen G","Poulet C","Deroyer C","Malaise MG","Cobraiville G","Malaise O","Plener Z","Daniel C","Ciregia F","de Seny D","Gillet P"],"additional_accession":[]},"is_claimable":false,"name":"CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane.","description":"Osteoarthritis (OA) synovial membrane is mainly characterized by low-grade inflammation, hyperplasia with increased cell proliferation and fibrosis. We previously underscored a critical role for CEMIP in fibrosis of OA cartilage. However, its role in OA synovial membrane remains unknown. An in vitro model with fibroblast-like synoviocytes from OA patients and an in vivo model with collagenase-induced OA mice were used to evaluate CEMIP-silencing effects on inflammation, hyperplasia and fibrosis. Our results showed that i. CEMIP expression was increased in human and mouse inflamed synovial membrane; ii. CEMIP regulated the inflammatory response pathway and inflammatory cytokines production in vitro and in vivo; iii. CEMIP induced epithelial to mesenchymal transition pathway and fibrotic mar","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-05-18T12:07:03.376Z","creation":"2025-02-19T03:58:21.685Z"},"accession":"S-EPMC9042994","cross_references":{"pubmed":["35474501"],"doi":["10.1007/s00018-022-04282-6"]}}