biostudies-literatureUnknown14Elbermawi AThe study evaluated prebiotic potential and the enzyme inhibition of extracts and isolated compounds of <i>Rumex vesicarius</i> (ruby dock), family Polygonaceae. Eight known compounds were identified in the roots of <i>R. vesicarius</i>. Extracts and compounds (<b>1</b>-<b>8</b>) increased the growth rate of <i>Escherichia coli</i> Nissle 1917 differentially compared to controls. The highest prebiotic index (PI) and activity score was recorded for EcN in the presence of compound <b>4</b>, followed by, in descending order, petroleum ether, ethyl acetate, and total methanol extracts. The compounds and extracts reduced protease, α-amylase, and angiotensin-converting enzyme activities. This inhibitory activity was positively correlated with PI, P_score, µ_u, and Y<sub>max</Food chemistry: X100306https://www.ebi.ac.uk/biostudies/studies/S-EPMC9043391biostudies-literatureIsolation and biological activities of compounds from <i>Rumex vesicarius</i> L. and their use as a component of a synbiotic preparation.PMC9043391Elbermawi AZaki AADarwish MSSamra RMEl-Awady AAQiu LfalseIsolation and biological activities of compounds from <i>Rumex vesicarius</i> L. and their use as a component of a synbiotic preparation.The study evaluated prebiotic potential and the enzyme inhibition of extracts and isolated compounds of <i>Rumex vesicarius</i> (ruby dock), family Polygonaceae. Eight known compounds were identified in the roots of <i>R. vesicarius</i>. Extracts and compounds (<b>1</b>-<b>8</b>) increased the growth rate of <i>Escherichia coli</i> Nissle 1917 differentially compared to controls. The highest prebiotic index (PI) and activity score was recorded for EcN in the presence of compound <b>4</b>, followed by, in descending order, petroleum ether, ethyl acetate, and total methanol extracts. The compounds and extracts reduced protease, α-amylase, and angiotensin-converting enzyme activities. This inhibitory activity was positively correlated with PI, P_score, µ_u, and Y<sub>max</2022-01-01T00:00:00Z2022 Jun2025-04-05T11:59:50.919Z2024-11-09T12:27:28.17ZS-EPMC90433913549225310.1016/j.fochx.2022.100306