{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Burclaff J"],"funding":["NICHD NIH HHS","NIDDK NIH HHS","NHLBI NIH HHS","UNC-Chapel Hill","NIGMS NIH HHS"],"pagination":["1554-1589"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9043569"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(5)"],"pubmed_abstract":["<h4>Background & aims</h4>Single-cell transcriptomics offer unprecedented resolution of tissue function at the cellular level, yet studies analyzing healthy adult human small intestine and colon are sparse. Here, we present single-cell transcriptomics covering the duodenum, jejunum, ileum, and ascending, transverse, and descending colon from 3 human beings.<h4>Methods</h4>A total of 12,590 single epithelial cells from 3 independently processed organ donors were evaluated for organ-specific lineage biomarkers, differentially regulated genes, receptors, and drug targets. Analyses focused on intrinsic cell properties and their capacity for response to extrinsic signals along the gut axis across different human beings.<h4>Results</h4>Cells were assigned to 25 epithelial lineage clusters. Multi"],"journal":["Cellular and molecular gastroenterology and hepatology"],"pubmed_title":["A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics."],"pmcid":["PMC9043569"],"funding_grant_id":["P30 DK065988","T32 GM133364","R00 GM102372","R01 GM138834","DP2 HD091800","R01 DK115806","F31 HL156433","F32 DK124929","T32 DK007737","R01 DK109559","P30 DK034987","F30 DK126307","T32 GM067553"],"pubmed_authors":["Gomez-Martinez I","Ok MT","Purvis JE","Woosley JT","Burclaff J","Bliton RJ","Ranek JS","Breau KA","Bhatt AP","Magness ST"],"additional_accession":[]},"is_claimable":false,"name":"A Proximal-to-Distal Survey of Healthy Adult Human Small Intestine and Colon Epithelium by Single-Cell Transcriptomics.","description":"<h4>Background & aims</h4>Single-cell transcriptomics offer unprecedented resolution of tissue function at the cellular level, yet studies analyzing healthy adult human small intestine and colon are sparse. Here, we present single-cell transcriptomics covering the duodenum, jejunum, ileum, and ascending, transverse, and descending colon from 3 human beings.<h4>Methods</h4>A total of 12,590 single epithelial cells from 3 independently processed organ donors were evaluated for organ-specific lineage biomarkers, differentially regulated genes, receptors, and drug targets. Analyses focused on intrinsic cell properties and their capacity for response to extrinsic signals along the gut axis across different human beings.<h4>Results</h4>Cells were assigned to 25 epithelial lineage clusters. Multi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-07-14T17:55:10.959Z","creation":"2025-04-04T19:32:33.049Z"},"accession":"S-EPMC9043569","cross_references":{"pubmed":["35176508"],"doi":["10.1016/j.jcmgh.2022.02.007"]}}