{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(59)"],"submitter":["Zhao F"],"pubmed_abstract":["Chemodynamic therapy (CDT) is a booming technology that utilizes Fenton reagents to kill tumor cells by transforming intracellular H<sub>2</sub>O<sub>2</sub> into reactive oxygen species (ROS), but insufficient endogenous H<sub>2</sub>O<sub>2</sub> makes it difficult to attain satisfactory antitumor results. In this article, a H<sub>2</sub>O<sub>2</sub>-free CDT technique with tumor-specificity is developed by using pH-sensitive magnetic iron carbide nanoparticles (PEG/Fe<sub>2</sub>C@Fe<sub>3</sub>O<sub>4</sub> NPs) to trigger artemisinin (ART) to <i>in situ</i> form ROS. ART-loaded PEG/Fe<sub>2</sub>C@Fe<sub>3</sub>O<sub>4</sub> NPs are fabricated for the enormous release of Fe<sup>2+</sup> ions induced by the acidic conditions of the tumor microenvironment after magnetic-assisted tumor "],"journal":["RSC advances"],"pagination":["37504-37513"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9043768"],"repository":["biostudies-literature"],"pubmed_title":["H<sub>2</sub>O<sub>2</sub>-independent chemodynamic therapy initiated from magnetic iron carbide nanoparticle-assisted artemisinin synergy."],"pmcid":["PMC9043768"],"pubmed_authors":["Su D","Li J","Yu J","Sun X","Yang X","Li W","Zheng J","Che S","Ying Y","Zhao F","Liang L","Gao W","Mou X","Qiao L","Cai W"],"additional_accession":[]},"is_claimable":false,"name":"H<sub>2</sub>O<sub>2</sub>-independent chemodynamic therapy initiated from magnetic iron carbide nanoparticle-assisted artemisinin synergy.","description":"Chemodynamic therapy (CDT) is a booming technology that utilizes Fenton reagents to kill tumor cells by transforming intracellular H<sub>2</sub>O<sub>2</sub> into reactive oxygen species (ROS), but insufficient endogenous H<sub>2</sub>O<sub>2</sub> makes it difficult to attain satisfactory antitumor results. In this article, a H<sub>2</sub>O<sub>2</sub>-free CDT technique with tumor-specificity is developed by using pH-sensitive magnetic iron carbide nanoparticles (PEG/Fe<sub>2</sub>C@Fe<sub>3</sub>O<sub>4</sub> NPs) to trigger artemisinin (ART) to <i>in situ</i> form ROS. ART-loaded PEG/Fe<sub>2</sub>C@Fe<sub>3</sub>O<sub>4</sub> NPs are fabricated for the enormous release of Fe<sup>2+</sup> ions induced by the acidic conditions of the tumor microenvironment after magnetic-assisted tumor ","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-04T08:36:40.047Z","creation":"2024-11-21T02:48:46.574Z"},"accession":"S-EPMC9043768","cross_references":{"pubmed":["35496387"],"doi":["10.1039/d1ra04975e"]}}