biostudies-literatureUnknown11(59)Zhao FChemodynamic therapy (CDT) is a booming technology that utilizes Fenton reagents to kill tumor cells by transforming intracellular H₂O₂ into reactive oxygen species (ROS), but insufficient endogenous H₂O₂ makes it difficult to attain satisfactory antitumor results. In this article, a H₂O₂-free CDT technique with tumor-specificity is developed by using pH-sensitive magnetic iron carbide nanoparticles (PEG/Fe₂C@Fe₃O₄ NPs) to trigger artemisinin (ART) to <i>in situ</i> form ROS. ART-loaded PEG/Fe₂C@Fe₃O₄ NPs are fabricated for the enormous release of Fe²⁺ ions induced by the acidic conditions of the tumor microenvironment after magnetic-assisted tumor RSC advances37504-37513https://www.ebi.ac.uk/biostudies/studies/S-EPMC9043768biostudies-literatureH₂O₂-independent chemodynamic therapy initiated from magnetic iron carbide nanoparticle-assisted artemisinin synergy.PMC9043768Su DLi JYu JSun XYang XLi WZheng JChe SYing YZhao FLiang LGao WMou XQiao LCai WfalseH₂O₂-independent chemodynamic therapy initiated from magnetic iron carbide nanoparticle-assisted artemisinin synergy.Chemodynamic therapy (CDT) is a booming technology that utilizes Fenton reagents to kill tumor cells by transforming intracellular H₂O₂ into reactive oxygen species (ROS), but insufficient endogenous H₂O₂ makes it difficult to attain satisfactory antitumor results. In this article, a H₂O₂-free CDT technique with tumor-specificity is developed by using pH-sensitive magnetic iron carbide nanoparticles (PEG/Fe₂C@Fe₃O₄ NPs) to trigger artemisinin (ART) to <i>in situ</i> form ROS. ART-loaded PEG/Fe₂C@Fe₃O₄ NPs are fabricated for the enormous release of Fe²⁺ ions induced by the acidic conditions of the tumor microenvironment after magnetic-assisted tumor 2021-01-01T00:00:00Z2021 Nov2025-04-04T08:36:40.047Z2024-11-21T02:48:46.574ZS-EPMC90437683549638710.1039/d1ra04975e