{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(59)"],"submitter":["Qiu X"],"pubmed_abstract":["A new one pot protocol has been developed for the reductive silylation of alkenyl methyl ethers using Et<sub>3</sub>Si-BPin and HSiEt<sub>3</sub> with nickel(ii) catalyst. Styrene type methyl ethers, multi-substituted vinyl methyl ethers, heterocycles and unconjugated vinyl ethers are all tolerated to form alkyl silanes. Mechanistic study reveals that it is a cascade of a C-O bond silylation and vinyl double bond hydrogenation process. Internal nucleophilic substitution or oxidative addition pathways were both acceptable for C-O bond cleavage. The acquired intermediate alkenyl silanes then proceeded through an unconventional reduction process thus providing alkyl silanes."],"journal":["RSC advances"],"pagination":["37083-37088"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9043817"],"repository":["biostudies-literature"],"pubmed_title":["Nickel(ii)-catalyzed reductive silylation of alkenyl methyl ethers for the synthesis of alkyl silanes."],"pmcid":["PMC9043817"],"pubmed_authors":["Zhou L","Lu L","Qiu X","Ling Y","Zhang Y","Wang H"],"additional_accession":[]},"is_claimable":false,"name":"Nickel(ii)-catalyzed reductive silylation of alkenyl methyl ethers for the synthesis of alkyl silanes.","description":"A new one pot protocol has been developed for the reductive silylation of alkenyl methyl ethers using Et<sub>3</sub>Si-BPin and HSiEt<sub>3</sub> with nickel(ii) catalyst. Styrene type methyl ethers, multi-substituted vinyl methyl ethers, heterocycles and unconjugated vinyl ethers are all tolerated to form alkyl silanes. Mechanistic study reveals that it is a cascade of a C-O bond silylation and vinyl double bond hydrogenation process. Internal nucleophilic substitution or oxidative addition pathways were both acceptable for C-O bond cleavage. The acquired intermediate alkenyl silanes then proceeded through an unconventional reduction process thus providing alkyl silanes.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2024-11-14T02:11:49.493Z","creation":"2024-11-14T02:11:49.493Z"},"accession":"S-EPMC9043817","cross_references":{"pubmed":["35496447"],"doi":["10.1039/d1ra07238b"]}}