biostudies-literatureAl-Enezi MYKuwait University37866-37876https://www.ebi.ac.uk/biostudies/studies/S-EPMC9044017biostudies-literatureUnknown11(60)Three novel phosphine-free Ru-alkylidenes (7a-7c) have been synthesized and utilized as efficient catalysts for ring closing metathesis (RCM) reaction. Spectroscopic data, <i>i.e.</i> NMR and HRMS, along with single crystal X-ray diffraction analysis, were used to confirm their chemical structures. The tosylated carbenoid 7b showed the highest efficiency in cyclizing different acyclic diene substrates. RCM of various (un)substituted <i>N</i>,<i>N</i>-diallylaniline derivatives and stereoselective RCM of different macromolecular dienes were well tolerated using only a catalytic amount (0.5-2.0 mol%) of the additive catalyst (7b) as compared to the well-known Grubbs (II) and Hoveyda-Grubbs (II) catalysts.RSC advancesHighly efficient Ru(ii)-alkylidene based Hoveyda-Grubbs catalysts for ring-closing metathesis reactions.PMC9044017SC 11/16John EIbrahim YAAl-Enezi MYAl-Awadi NAfalseHighly efficient Ru(ii)-alkylidene based Hoveyda-Grubbs catalysts for ring-closing metathesis reactions.Three novel phosphine-free Ru-alkylidenes (7a-7c) have been synthesized and utilized as efficient catalysts for ring closing metathesis (RCM) reaction. Spectroscopic data, <i>i.e.</i> NMR and HRMS, along with single crystal X-ray diffraction analysis, were used to confirm their chemical structures. The tosylated carbenoid 7b showed the highest efficiency in cyclizing different acyclic diene substrates. RCM of various (un)substituted <i>N</i>,<i>N</i>-diallylaniline derivatives and stereoselective RCM of different macromolecular dienes were well tolerated using only a catalytic amount (0.5-2.0 mol%) of the additive catalyst (7b) as compared to the well-known Grubbs (II) and Hoveyda-Grubbs (II) catalysts.2021-01-01T00:00:00Z2021 Nov2025-04-05T14:42:55.888Z2025-04-05T14:42:55.888ZS-EPMC90440173549807610.1039/d1ra07428h