biostudies-literatureUnknown11(61)Athar MSwiss National Science FoundationUiO-66 is a versatile zirconium-based MOF, which is thermally stable up to 500 °C. In the present work, the thermal degradation of UiO-66 with a high number of defects has been studied in inert, oxidative and reductive environments. A sample of UiO-66 with a high BET surface area of 1827 m² g^-1 was prepared, which contains 2.3 missing linkers per hexa-zirconium node, as calculated by the thermogravimetric curve. The crystalline framework of this UiO-66 sample collapses at 250 °C, while thermal decomposition starts at 450 °C in the oxidative environment and at 500 °C in the reductive and inert environments. The BET surface area of the MOF is affected variably by heating under different gaseous conditions. Under inert conditions, porosity is maintained up to 711 m<sup>2RSC advances38849-38855https://www.ebi.ac.uk/biostudies/studies/S-EPMC9044256biostudies-literatureThermal degradation of defective high-surface-area UiO-66 in different gaseous environments.PMC9044256Ranocchiari MAnton van Bokhoven JRzepka PAthar MThoeny DfalseThermal degradation of defective high-surface-area UiO-66 in different gaseous environments.UiO-66 is a versatile zirconium-based MOF, which is thermally stable up to 500 °C. In the present work, the thermal degradation of UiO-66 with a high number of defects has been studied in inert, oxidative and reductive environments. A sample of UiO-66 with a high BET surface area of 1827 m² g^-1 was prepared, which contains 2.3 missing linkers per hexa-zirconium node, as calculated by the thermogravimetric curve. The crystalline framework of this UiO-66 sample collapses at 250 °C, while thermal decomposition starts at 450 °C in the oxidative environment and at 500 °C in the reductive and inert environments. The BET surface area of the MOF is affected variably by heating under different gaseous conditions. Under inert conditions, porosity is maintained up to 711 m<sup>22021-01-01T00:00:00Z2021 Nov2025-05-18T12:06:34.677Z2025-04-06T19:15:12.7ZS-EPMC90442563549325810.1039/d1ra05411b