{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["11(61)"],"submitter":["Cui M"],"pubmed_abstract":["Herein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Moreover, good yields with excellent functional group tolerance are successfully achieved for a range of substrates, including aryl and heteroaryl groups, terminal alkynes and internal alkynes, and various triazole derivatives. This work presents an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach."],"journal":["RSC advances"],"pagination":["38933-38937"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9044274"],"repository":["biostudies-literature"],"pubmed_title":["Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions."],"pmcid":["PMC9044274"],"pubmed_authors":["Cui M","Su C","Wang R","Kuang C","Yang Q"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions.","description":"Herein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Moreover, good yields with excellent functional group tolerance are successfully achieved for a range of substrates, including aryl and heteroaryl groups, terminal alkynes and internal alkynes, and various triazole derivatives. This work presents an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Nov","modification":"2025-04-19T00:42:25.406Z","creation":"2025-04-07T11:44:49.093Z"},"accession":"S-EPMC9044274","cross_references":{"pubmed":["35493263"],"doi":["10.1039/d1ra08322h"]}}