biostudies-literatureUnknown11(61)Cui MHerein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Moreover, good yields with excellent functional group tolerance are successfully achieved for a range of substrates, including aryl and heteroaryl groups, terminal alkynes and internal alkynes, and various triazole derivatives. This work presents an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach.RSC advances38933-38937https://www.ebi.ac.uk/biostudies/studies/S-EPMC9044274biostudies-literatureSynthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions.PMC9044274Cui MSu CWang RKuang CYang QfalseSynthesis of vinyl-1,2,3-triazole derivatives under transition metal-free conditions.Herein, we describe a novel and green route for the direct synthesis of vinyl triazole derivatives with alkynes and triazoles promoted by an inorganic base under transition metal-free conditions. The base shows great catalytic activity for the anti-Markovnikov stereoselective hydroamination of alkynes. Moreover, good yields with excellent functional group tolerance are successfully achieved for a range of substrates, including aryl and heteroaryl groups, terminal alkynes and internal alkynes, and various triazole derivatives. This work presents an advanced concept for the synthesis of alkenyl triazole with a versatile and cost-efficient approach.2021-01-01T00:00:00Z2021 Nov2025-04-19T00:42:25.406Z2025-04-07T11:44:49.093ZS-EPMC90442743549326310.1039/d1ra08322h