biostudies-literatureHu CNational Natural Science Foundation of China39287-39290https://www.ebi.ac.uk/biostudies/studies/S-EPMC9044443biostudies-literatureUnknown11(62)In this work, we report a novel probe IR-RGD, which possesses a bright emission tail in the NIR-II region along with high quantum yield. Further, IR-RGD has been successfully used for tumor-targeting NIR-II fluorescence imaging with great potential for clinical translation.RSC advancesA novel NIR-II probe for improved tumor-targeting NIR-II imaging.PMC90444438180181381701754Li HHu CXu PXiao YGuo TfalseA novel NIR-II probe for improved tumor-targeting NIR-II imaging.In this work, we report a novel probe IR-RGD, which possesses a bright emission tail in the NIR-II region along with high quantum yield. Further, IR-RGD has been successfully used for tumor-targeting NIR-II fluorescence imaging with great potential for clinical translation.2021-01-01T00:00:00Z2021 Dec2025-04-19T00:43:05.605Z2025-04-07T11:45:31.434ZS-EPMC90444433549248110.1039/d1ra07135a