{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(2)"],"submitter":["Lotankar M"],"funding":["Janssen Research and Development, LLC","Sydäntutkimussäätiö","Academy of Finland","Juho Vainion Säätiö","The Biocodex foundation","Diabetestutkimussäätiö"],"pubmed_abstract":["Diet and gut microbiota are known to modulate metabolic health. Our aim was to apply a metagenomics approach to investigate whether the diet-gut microbiota-metabolism and inflammation relationships differ in pregnant overweight and obese women. This cross-sectional study was conducted in overweight (<i>n</i> = 234) and obese (<i>n</i> = 152) women during early pregnancy. Dietary quality was measured by a validated index of diet quality (IDQ). Gut microbiota taxonomic composition and species diversity were assessed by metagenomic profiling (Illumina HiSeq platform). Markers for glucose metabolism (glucose, insulin) and low-grade inflammation (high sensitivity C-reactive protein [hsCRP], glycoprotein acetylation [GlycA]) were analyzed from blood samples. Higher IDQ scores were positively ass"],"journal":["Microbiology spectrum"],"pagination":["e0089321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9045358"],"repository":["biostudies-literature"],"pubmed_title":["Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach."],"pmcid":["PMC9045358"],"pubmed_authors":["Koivuniemi E","Nielsen HB","Sorensen N","Lahti L","Mokkala K","Houttu N","Laitinen K","Lotankar M","Munukka E"],"additional_accession":[]},"is_claimable":false,"name":"Distinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach.","description":"Diet and gut microbiota are known to modulate metabolic health. Our aim was to apply a metagenomics approach to investigate whether the diet-gut microbiota-metabolism and inflammation relationships differ in pregnant overweight and obese women. This cross-sectional study was conducted in overweight (<i>n</i> = 234) and obese (<i>n</i> = 152) women during early pregnancy. Dietary quality was measured by a validated index of diet quality (IDQ). Gut microbiota taxonomic composition and species diversity were assessed by metagenomic profiling (Illumina HiSeq platform). Markers for glucose metabolism (glucose, insulin) and low-grade inflammation (high sensitivity C-reactive protein [hsCRP], glycoprotein acetylation [GlycA]) were analyzed from blood samples. Higher IDQ scores were positively ass","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-07-14T15:50:00.731Z","creation":"2025-04-04T12:45:06.17Z"},"accession":"S-EPMC9045358","cross_references":{"pubmed":["35343768"],"doi":["10.1128/spectrum.00893-21"]}}