biostudies-literatureUnknown10(2)Lotankar MJanssen Research and Development, LLCSydäntutkimussäätiöAcademy of FinlandJuho Vainion SäätiöThe Biocodex foundationDiabetestutkimussäätiöDiet and gut microbiota are known to modulate metabolic health. Our aim was to apply a metagenomics approach to investigate whether the diet-gut microbiota-metabolism and inflammation relationships differ in pregnant overweight and obese women. This cross-sectional study was conducted in overweight (<i>n</i> = 234) and obese (<i>n</i> = 152) women during early pregnancy. Dietary quality was measured by a validated index of diet quality (IDQ). Gut microbiota taxonomic composition and species diversity were assessed by metagenomic profiling (Illumina HiSeq platform). Markers for glucose metabolism (glucose, insulin) and low-grade inflammation (high sensitivity C-reactive protein [hsCRP], glycoprotein acetylation [GlycA]) were analyzed from blood samples. Higher IDQ scores were positively assMicrobiology spectrume0089321https://www.ebi.ac.uk/biostudies/studies/S-EPMC9045358biostudies-literatureDistinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach.PMC9045358Koivuniemi ENielsen HBSorensen NLahti LMokkala KHouttu NLaitinen KLotankar MMunukka EfalseDistinct Diet-Microbiota-Metabolism Interactions in Overweight and Obese Pregnant Women: a Metagenomics Approach.Diet and gut microbiota are known to modulate metabolic health. Our aim was to apply a metagenomics approach to investigate whether the diet-gut microbiota-metabolism and inflammation relationships differ in pregnant overweight and obese women. This cross-sectional study was conducted in overweight (<i>n</i> = 234) and obese (<i>n</i> = 152) women during early pregnancy. Dietary quality was measured by a validated index of diet quality (IDQ). Gut microbiota taxonomic composition and species diversity were assessed by metagenomic profiling (Illumina HiSeq platform). Markers for glucose metabolism (glucose, insulin) and low-grade inflammation (high sensitivity C-reactive protein [hsCRP], glycoprotein acetylation [GlycA]) were analyzed from blood samples. Higher IDQ scores were positively ass2022-01-01T00:00:00Z2022 Apr2026-07-14T15:50:00.731Z2025-04-04T12:45:06.17ZS-EPMC90453583534376810.1128/spectrum.00893-21