{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lin C"],"funding":["National Key Research and Development Program of China","Canadian Institutes of Health Research","CIHR"],"pagination":["e0044321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9045381"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(2)"],"pubmed_abstract":["Granulomas are the pathological hallmark of tuberculosis (TB). In individuals with latent TB infection, Mycobacterium tuberculosis cells reside within granulomas in a nonreplicating dormant state, and a portion of them will develop active TB. Little is known on the bacterial mechanisms/factors involved in this process. In this study, we found that WhiB4, an oxygen sensor and a transcription factor, plays a critical role in disease progression and reactivation of Mycobacterium marinum (M. marinum) infection in zebrafish. We show that the <i>whiB4</i>::Tn mutant of M. marinum caused persistent infection in adult zebrafish, which is characterized by the lower but stable bacterial loads, constant number of nonnecrotized granulomas in fewer organs, and reduced inflammation compared to those of "],"journal":["Microbiology spectrum"],"pubmed_title":["WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish."],"pmcid":["PMC9045381"],"funding_grant_id":["No.2018YFD0500900","PJT-173353","PJT-156261"],"pubmed_authors":["Li Y","Liu J","Lin C","Zhang J","Xu S","Xia B","Zhang L","Wang Y","Zhai Q","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"WhiB4 Is Required for the Reactivation of Persistent Infection of Mycobacterium marinum in Zebrafish.","description":"Granulomas are the pathological hallmark of tuberculosis (TB). In individuals with latent TB infection, Mycobacterium tuberculosis cells reside within granulomas in a nonreplicating dormant state, and a portion of them will develop active TB. Little is known on the bacterial mechanisms/factors involved in this process. In this study, we found that WhiB4, an oxygen sensor and a transcription factor, plays a critical role in disease progression and reactivation of Mycobacterium marinum (M. marinum) infection in zebrafish. We show that the <i>whiB4</i>::Tn mutant of M. marinum caused persistent infection in adult zebrafish, which is characterized by the lower but stable bacterial loads, constant number of nonnecrotized granulomas in fewer organs, and reduced inflammation compared to those of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-10T06:20:35.278Z","creation":"2025-04-04T09:19:54.686Z"},"accession":"S-EPMC9045381","cross_references":{"pubmed":["35266819"],"doi":["10.1128/spectrum.00443-21"]}}