biostudies-literatureHaskey NCanadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of CanadaCrohn’s and Colitis Canada GrantCrohn’s and Colitis CanadaCanadian Institutes of Health ResearchCanadian Association of Gastroenterology2055441https://www.ebi.ac.uk/biostudies/studies/S-EPMC9045830biostudies-literatureUnknown14(1)There is a growing appreciation that the interaction between diet, the gut microbiota and the immune system contribute to the development and progression of inflammatory bowel disease (IBD). A mounting body of scientific evidence suggests that high-fat diets exacerbate IBD; however, there is a lack of information on how specific types of fat impact colitis. The Mediterranean diet (MD) is considered a health-promoting diet containing approximately 40% total fat. It is not known if the blend of fats found in the MD contributes to its beneficial protective effects.Mice deficient in the mucin 2 gene (Muc 2^-/-) were weaned to 40% fat, isocaloric, isonitrogenous diets. We compared the MD fat blend (high monounsaturated, 2:1 n-6:n-3 polyunsaturated and moderate saturated fat) to diets Gut microbesA Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model.PMC9045830Grant-in- AidHaskey NGhosh SGibson DLYousefi MBirnie BWVerdugo Meza AAGruenheid SEstaki MYe JBarnett JAfalseA Mediterranean-like fat blend protects against the development of severe colitis in the mucin-2 deficient murine model.There is a growing appreciation that the interaction between diet, the gut microbiota and the immune system contribute to the development and progression of inflammatory bowel disease (IBD). A mounting body of scientific evidence suggests that high-fat diets exacerbate IBD; however, there is a lack of information on how specific types of fat impact colitis. The Mediterranean diet (MD) is considered a health-promoting diet containing approximately 40% total fat. It is not known if the blend of fats found in the MD contributes to its beneficial protective effects.Mice deficient in the mucin 2 gene (Muc 2^-/-) were weaned to 40% fat, isocaloric, isonitrogenous diets. We compared the MD fat blend (high monounsaturated, 2:1 n-6:n-3 polyunsaturated and moderate saturated fat) to diets 2022-01-01T00:00:00Z2022 Jan-Dec2025-04-05T15:46:11.858Z2024-12-03T18:58:55.594ZS-EPMC90458303547111910.1080/19490976.2022.2055441