{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wojtkiewicz S"],"funding":["Nalecz Institute of Biocybernetics and                         Biomedical Engineering","Narodowe Centrum Nauki"],"pagination":["1869-1887"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9045899"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(4)"],"pubmed_abstract":["Here we show a method of the lock-in amplifying near-infrared signals originating within a human brain. It implies using two 90-degree rotated source-detector pairs fixed on a head surface. Both pairs have a joint sensitivity region located towards the brain. A direct application of the lock-in technique on both signals results in amplifying common frequency components, e.g. related to brain cortex stimulation and attenuating the rest, including all components not related to the stimulation: e.g. pulse, instrumental and biological noise or movement artefacts. This is a self-driven method as no prior assumptions are needed and the noise model is provided by the interfering signals themselves. We show the theory (classical modified Beer-Lambert law and diffuse optical tomography approaches),"],"journal":["Biomedical optics express"],"pubmed_title":["Lock-in functional near-infrared spectroscopy for measurement of the haemodynamic brain response."],"pmcid":["PMC9045899"],"funding_grant_id":["2012/05/B/ST7/01162","2020/39/D/ST7/03425","ST213/2021","2016/21/N/ST7/03117"],"pubmed_authors":["Bejm K","Wojtkiewicz S","Liebert A"],"additional_accession":[]},"is_claimable":false,"name":"Lock-in functional near-infrared spectroscopy for measurement of the haemodynamic brain response.","description":"Here we show a method of the lock-in amplifying near-infrared signals originating within a human brain. It implies using two 90-degree rotated source-detector pairs fixed on a head surface. Both pairs have a joint sensitivity region located towards the brain. A direct application of the lock-in technique on both signals results in amplifying common frequency components, e.g. related to brain cortex stimulation and attenuating the rest, including all components not related to the stimulation: e.g. pulse, instrumental and biological noise or movement artefacts. This is a self-driven method as no prior assumptions are needed and the noise model is provided by the interfering signals themselves. We show the theory (classical modified Beer-Lambert law and diffuse optical tomography approaches),","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-12T05:47:54.454Z","creation":"2026-06-12T03:08:19.543Z"},"accession":"S-EPMC9045899","cross_references":{"pubmed":["35519260"],"doi":["10.1364/boe.448038","10.1364/BOE.448038"]}}