biostudies-literatureUnknown12Low LFight for Sight UKNational Institute for Health Research (NIHR)Mucous Membrane Pemphigoid is an orphan multi-system autoimmune scarring disease involving mucosal sites, including the ocular surface (OcMMP) and gut. Loss of tolerance to epithelial basement membrane proteins and generation of autoreactive T cell and/or autoantibodies are central to the disease process. The gut microbiome plays a critical role in the development of the immune system. Alteration in the gut microbiome (gut dysbiosis) affects the generation of autoreactive T cells and B cell autoantibody repertoire in several autoimmune conditions. This study examines the relationship between gut microbiome diversity and ocular inflammation in patients with OcMMP by comparing OcMMP gut microbiome profiles with healthy controls. DNA was extracted from faecal samples (49 OcMMP patients, 40 heFrontiers in cellular and infection microbiology780354https://www.ebi.ac.uk/biostudies/studies/S-EPMC9046938biostudies-literatureGut Dysbiosis in Ocular Mucous Membrane Pemphigoid.PMC9046938Suleiman KLow LAcharjee ALoman NMurray PIShamdas MWallace GRPoonit NRauz SBassilious KRossiter AEfalseGut Dysbiosis in Ocular Mucous Membrane Pemphigoid.Mucous Membrane Pemphigoid is an orphan multi-system autoimmune scarring disease involving mucosal sites, including the ocular surface (OcMMP) and gut. Loss of tolerance to epithelial basement membrane proteins and generation of autoreactive T cell and/or autoantibodies are central to the disease process. The gut microbiome plays a critical role in the development of the immune system. Alteration in the gut microbiome (gut dysbiosis) affects the generation of autoreactive T cells and B cell autoantibody repertoire in several autoimmune conditions. This study examines the relationship between gut microbiome diversity and ocular inflammation in patients with OcMMP by comparing OcMMP gut microbiome profiles with healthy controls. DNA was extracted from faecal samples (49 OcMMP patients, 40 he2022-01-01T00:00:00Z20222025-04-05T09:57:57.239Z2025-04-05T09:57:57.239ZS-EPMC90469383549374010.3389/fcimb.2022.780354